Mapping CAC susceptibility loci with single-cell resolution in carotid plaques.
A ‘druggable-MI-targets’ project
Sander W. van der Laan, PhD | @swvanderlaan
2021-07-17
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[1] "AESCRNA" "scRNAseq.nb.html" "scRNAseq.Rmd" … a package-installation function …
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1 ERA-CVD ‘druggable-MI-targets’
For the ERA-CVD ‘druggable-MI-targets’ project (grantnumber: 01KL1802) we will perform two related RNA sequencing (RNAseq) experiments:
conventional (‘bulk’) RNAseq using RNA extracted from carotid plaque samples, n ± 700. As of Friday, July 16, 2021 all samples have been selected and RNA has been extracted; quality control (QC) was performed and we have a dataset of 635 samples.
single-cell RNAseq (scRNAseq) of at least n = 40 samples (20 females, 20 males). As of Friday, July 16, 2021 data is available of 40 samples (3 females, 15 males), we are extending sampling to get more female samples.
Plaque samples are derived from carotid endarterectomies as part of the Athero-Express Biobank Study which is an ongoing study in the UMC Utrecht.
2 Background
Here we map the CHARGE Consortium 1000G GWAS on coronary artery calcification (CAC) susceptibility loci to the single-cell carotid plaque data. These are given in:
IndSigSNPsforSander.xlsxGeneList_15042020.xlsx
library(openxlsx)
CAC_gene_list <- read.xlsx(paste0(PROJECT_loc, "/SNP/Genes.xlsx"))
CAC_variants <- read.xlsx(paste0(PROJECT_loc, "/SNP/Variants.xlsx"))
DT::datatable(CAC_gene_list)
DT::datatable(CAC_variants)NAWe will construct a list of genes to map to our scRNAseq data.
target_genes <- unlist(CAC_gene_list$Gene)
target_genes [1] "C6orf195" "EDN1" "PHACTR1" "TBC1D7" "GFOD1" "ENPP1" "ENPP3" "IGFBP3"
[9] "AC011294.3" "MTAP" "RP11-145E5.5" "C9orf53" "CDKN2A" "CDKN2B" "ZNF485" "ZNF32"
[17] "AL137026.1" "ARID5B" "RTKN2" "CAMK2G" "VCL" "AP3M1" "ADK" "KAT6B"
[25] "DUPD1" "DUSP13" "SAMD8" "VDAC2" "COMTD1" "FGF23" "COL4A1" "COL4A2"
[33] "CHRNA5" "CHRNB4" "ADAMTS7" "MORF4L1" "CTSH" "BCAM" "PVRL2" "TOMM40"
[41] "APOE" "APOC1" 3 Load data
First we will load the data:
- scRNAseq experimental data and rename the cell types.
- Athero-Express clinical data.
3.1 AESCRNA: single-cell RNAseq from carotid plaques
Here we load the latest dataset from our Athero-Express Single Cell RNA experiment.
scRNAseqData <- readRDS(paste0(RAWDATA, "/Seuset_40_patients/20210217_PlaqView_38_pts.RDS"))
scRNAseqDataAn object of class Seurat
38835 features across 6191 samples within 2 assays
Active assay: SCT (18283 features, 3000 variable features)
1 other assay present: RNA
2 dimensional reductions calculated: pca, umapThe naming/classification is based on a combination conventional markers. We do not claim to know the exact identity of each cell, rather we refer to cells as ‘KIT+ Mast cells"-like cells. Likewise we refer to the cell clusters as ’communities’ of cells that exihibit similar properties, i.e. similar defining markers (e.g. KIT).
We will rename the cell types to human readable names.
### change names for clarity
# backup.scRNAseqData = scRNAseqData
# get the old names to change to new names
UMAPPlot(backup.scRNAseqData, label = FALSE, pt.size = 1.25, label.size = 4, group.by = "ident")
levels(unique(backup.scRNAseqData@active.ident)) [1] "CD3+CD8A+ T cells I" "CD3+CD8A+ T cells III" "CD3+CD4+ T Cells I" "CD14+CD68+ Macrophages I"
[5] "Mixed Cells I" "CD3+CD8A+ T Cells II" "CD14+CD68+ Macrophages II" "CD3+CD4+ T Cells II"
[9] "ACTA2+ Smooth Muscle Cells" "CD34+ Endothelial Cells I" "CD34+ Endothelial Cells II" "NCAM1+ Natural Killer Cells"
[13] "Mixed Cells II" "CD79A+ B Cells I" "CD14+CD68+ Macrophages III" "CD3+ Regulatory T Cells"
[17] "KIT+ Mast Cells" "CD79A+ B Cells II" # "CD3+CD8A+ T cells I" "CD3+CD8A+ T cells III" "CD3+CD4+ T Cells I" "CD14+CD68+ Macrophages I"
# "Mixed Cells I" "CD3+CD8A+ T Cells II" "CD14+CD68+ Macrophages II" "CD3+CD4+ T Cells II"
# "ACTA2+ Smooth Muscle Cells" "CD34+ Endothelial Cells I" "CD34+ Endothelial Cells II" "NCAM1+ Natural Killer Cells"
# "Mixed Cells II" "CD79A+ B Cells I" "CD14+CD68+ Macrophages III" "CD3+ Regulatory T Cells"
# "KIT+ Mast Cells" "CD79A+ B Cells II"
celltypes <- c("CD14+CD68+ Macrophages I" = "CD14+CD68+ M I",
"CD14+CD68+ Macrophages II" = "CD14+CD68+ M II",
"CD14+CD68+ Macrophages III" = "CD14+CD68+ M III",
"CD3+CD8A+ T cells I" = "CD3+CD8A+ T I",
"CD3+CD8A+ T Cells II" = "CD3+CD8A+ T II ",
"CD3+CD8A+ T cells III" = "CD3+CD8A+ T III",
"CD3+CD4+ T Cells I" = "CD3+CD4+ T I",
"CD3+CD4+ T Cells II" = "CD3+CD4+ T II",
"CD3+ Regulatory T Cells" = "CD3+ Treg",
"CD34+ Endothelial Cells I" = "CD34+ EC I",
"CD34+ Endothelial Cells II" = "CD34+ EC II",
"Mixed Cells I" = "Mixed I",
"Mixed Cells II" = "Mixed II",
"ACTA2+ Smooth Muscle Cells" = "ACTA2+ SMC",
"NCAM1+ Natural Killer Cells" = "NCAM1+ NK",
"KIT+ Mast Cells" = "KIT+ MC",
"CD79A+ B Cells I" = "CD79A+ B I",
"CD79A+ B Cells II" = "CD79A+ B II")
scRNAseqData <- Seurat::RenameIdents(object = backup.scRNAseqData,
celltypes)
UMAPPlot(scRNAseqData, label = FALSE, pt.size = 1.25, label.size = 4, group.by = "ident")
UMAPPlot(scRNAseqData, label = TRUE, pt.size = 1.25, label.size = 4, group.by = "ident",
repel = TRUE)
3.2 Athero-Express Biobank Study: clinical data
Loading Athero-Express clinical data.
require(haven)
# AEDB <- haven::read_sav(paste0(AEDB_loc, "/2019-3NEW_AtheroExpressDatabase_ScientificAE_02072019_IC_added.sav"))
AEDB <- haven::read_sav(paste0(AEDB_loc, "/2020_1_NEW_AtheroExpressDatabase_ScientificAE_16-03-2020.sav"))
3.2.1 Fix clinical data
We need to be very strict in defining symptoms. Therefore we will fix a new variable that groups symptoms at inclusion.
Coding of symptoms is as follows:
- missing -999
- Asymptomatic 0
- TIA 1
- minor stroke 2
- Major stroke 3
- Amaurosis fugax 4
- Four vessel disease 5
- Vertebrobasilary TIA 7
- Retinal infarction 8
- Symptomatic, but aspecific symtoms 9
- Contralateral symptomatic occlusion 10
- retinal infarction 11
- armclaudication due to occlusion subclavian artery, CEA needed for bypass 12
- retinal infarction + TIAs 13
- Ocular ischemic syndrome 14
- ischemisch glaucoom 15
- subclavian steal syndrome 16
- TGA 17
We will group as follows:
- Asymptomatic > 0
- TIA > 1, 7, 13
- Stroke > 2, 3
- Ocular > 4, 14, 15
- Retinal infarction > 8, 11
- Other > 5, 9, 10, 12, 16, 17
# Fix symptoms
attach(AEDB)
AEDB[,"Symptoms.5G"] <- NA
AEDB$Symptoms.5G[sympt == 0] <- "Asymptomatic"
AEDB$Symptoms.5G[sympt == 1 | sympt == 7 | sympt == 13] <- "TIA"
AEDB$Symptoms.5G[sympt == 2 | sympt == 3] <- "Stroke"
AEDB$Symptoms.5G[sympt == 4 | sympt == 14 | sympt == 15 ] <- "Ocular"
AEDB$Symptoms.5G[sympt == 8 | sympt == 11] <- "Retinal infarction"
AEDB$Symptoms.5G[sympt == 5 | sympt == 9 | sympt == 10 | sympt == 12 | sympt == 16 | sympt == 17] <- "Other"
# AsymptSympt
AEDB[,"AsymptSympt"] <- NA
AEDB$AsymptSympt[sympt == -999] <- NA
AEDB$AsymptSympt[sympt == 0] <- "Asymptomatic"
AEDB$AsymptSympt[sympt == 1 | sympt == 7 | sympt == 13 | sympt == 2 | sympt == 3] <- "Symptomatic"
AEDB$AsymptSympt[sympt == 4 | sympt == 14 | sympt == 15 | sympt == 8 | sympt == 11 | sympt == 5 | sympt == 9 | sympt == 10 | sympt == 12 | sympt == 16 | sympt == 17] <- "Ocular and others"
# AsymptSympt
AEDB[,"AsymptSympt2G"] <- NA
AEDB$AsymptSympt2G[sympt == -999] <- NA
AEDB$AsymptSympt2G[sympt == 0] <- "Asymptomatic"
AEDB$AsymptSympt2G[sympt == 1 | sympt == 7 | sympt == 13 | sympt == 2 | sympt == 3 | sympt == 4 | sympt == 14 | sympt == 15 | sympt == 8 | sympt == 11 | sympt == 5 | sympt == 9 | sympt == 10 | sympt == 12 | sympt == 16 | sympt == 17] <- "Symptomatic"
detach(AEDB)
# table(AEDB$sympt, useNA = "ifany")
# table(AEDB$AsymptSympt2G, useNA = "ifany")
# table(AEDB$Symptoms.5G, useNA = "ifany")
#
# table(AEDB$AsymptSympt2G, AEDB$sympt, useNA = "ifany")
# table(AEDB$Symptoms.5G, AEDB$sympt, useNA = "ifany")
table(AEDB$AsymptSympt2G, AEDB$Symptoms.5G, useNA = "ifany")
Asymptomatic Ocular Other Retinal infarction Stroke TIA <NA>
Asymptomatic 333 0 0 0 0 0 0
Symptomatic 0 416 119 43 732 1045 0
<NA> 0 0 0 0 0 0 1103# AEDB.temp <- subset(AEDB, select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "sympt", "Symptoms.5G", "AsymptSympt"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
#
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
#
# table(AEDB.temp$Symptoms.5G, AEDB.temp$AsymptSympt)
#
# rm(AEDB.temp)We will also fix the plaquephenotypes variable.
Coding of symptoms is as follows:
- missing -999
- not relevant -888
- fibrous 1
- fibroatheromatous 2
- atheromatous 3
# Fix plaquephenotypes
attach(AEDB)
AEDB[,"OverallPlaquePhenotype"] <- NA
AEDB$OverallPlaquePhenotype[plaquephenotype == -999] <- NA
AEDB$OverallPlaquePhenotype[plaquephenotype == -999] <- NA
AEDB$OverallPlaquePhenotype[plaquephenotype == 1] <- "fibrous"
AEDB$OverallPlaquePhenotype[plaquephenotype == 2] <- "fibroatheromatous"
AEDB$OverallPlaquePhenotype[plaquephenotype == 3] <- "atheromatous"
detach(AEDB)
# AEDB.temp <- subset(AEDB, select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "plaquephenotype", "OverallPlaquePhenotype"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
#
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
#
# rm(AEDB.temp)
We will also fix the diabetes status variable.
# Fix diabetes
attach(AEDB)
AEDB[,"DiabetesStatus"] <- NA
AEDB$DiabetesStatus[DM.composite == -999] <- NA
AEDB$DiabetesStatus[DM.composite == 0] <- "Control (no Diabetes Dx/Med)"
AEDB$DiabetesStatus[DM.composite == 1] <- "Diabetes"
detach(AEDB)
table(AEDB$DM.composite, AEDB$DiabetesStatus)
Control (no Diabetes Dx/Med) Diabetes
0 2764 0
1 0 985# AEDB.temp <- subset(AEDB, select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "DM.composite", "DiabetesStatus"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# AEDB.temp$DiabetesStatus <- to_factor(AEDB.temp$DiabetesStatus)
#
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
#
# rm(AEDB.temp)
We will also fix the smoking status variable. We are interested in whether someone never, ever or is currently (at the time of inclusion) smoking. This is based on the questionnaire.
diet801: are you a smoker?diet802: did you smoke in the past?
We already have some variables indicating smoking status:
SmokingReported: patient has reported to smoke.SmokingYearOR: smoking in the year of surgery?SmokerCurrent: currently smoking?
require(labelled)Loading required package: labelledAEDB$diet801 <- to_factor(AEDB$diet801)
AEDB$diet802 <- to_factor(AEDB$diet802)
AEDB$diet805 <- to_factor(AEDB$diet805)
AEDB$SmokingReported <- to_factor(AEDB$SmokingReported)
AEDB$SmokerCurrent <- to_factor(AEDB$SmokerCurrent)
AEDB$SmokingYearOR <- to_factor(AEDB$SmokingYearOR)
# table(AEDB$diet801)
# table(AEDB$diet802)
# table(AEDB$SmokingReported)
# table(AEDB$SmokerCurrent)
# table(AEDB$SmokingYearOR)
# table(AEDB$SmokingReported, AEDB$SmokerCurrent, useNA = "ifany", dnn = c("Reported smoking", "Current smoker"))
#
# table(AEDB$diet801, AEDB$diet802, useNA = "ifany", dnn = c("Smoker", "Past smoker"))
cat("\nFixing smoking status.\n")
Fixing smoking status.attach(AEDB)
AEDB[,"SmokerStatus"] <- NA
AEDB$SmokerStatus[diet802 == "don't know"] <- "Never smoked"
AEDB$SmokerStatus[diet802 == "I still smoke"] <- "Current smoker"
AEDB$SmokerStatus[SmokerCurrent == "no" & diet802 == "no"] <- "Never smoked"
AEDB$SmokerStatus[SmokerCurrent == "no" & diet802 == "yes"] <- "Ex-smoker"
AEDB$SmokerStatus[SmokerCurrent == "yes"] <- "Current smoker"
AEDB$SmokerStatus[SmokerCurrent == "no data available/missing"] <- NA
# AEDB$SmokerStatus[is.na(SmokerCurrent)] <- "Never smoked"
detach(AEDB)
cat("\n* Current smoking status.\n")
* Current smoking status.table(AEDB$SmokerCurrent,
useNA = "ifany",
dnn = c("Current smoker"))Current smoker
no data available/missing no yes <NA>
0 2364 1308 119 cat("\n* Updated smoking status.\n")
* Updated smoking status.table(AEDB$SmokerStatus,
useNA = "ifany",
dnn = c("Updated smoking status"))Updated smoking status
Current smoker Ex-smoker Never smoked <NA>
1308 1814 389 280 cat("\n* Comparing to 'SmokerCurrent'.\n")
* Comparing to 'SmokerCurrent'.table(AEDB$SmokerStatus, AEDB$SmokerCurrent,
useNA = "ifany",
dnn = c("Updated smoking status", "Current smoker")) Current smoker
Updated smoking status no data available/missing no yes <NA>
Current smoker 0 0 1308 0
Ex-smoker 0 1814 0 0
Never smoked 0 389 0 0
<NA> 0 161 0 119# AEDB.temp <- subset(AEDB, select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "DM.composite", "DiabetesStatus"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# AEDB.temp$DiabetesStatus <- to_factor(AEDB.temp$DiabetesStatus)
#
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
#
# rm(AEDB.temp)
We will also fix the alcohol status variable.
# Fix diabetes
attach(AEDB)
AEDB[,"AlcoholUse"] <- NA
AEDB$AlcoholUse[diet810 == -999] <- NA
AEDB$AlcoholUse[diet810 == 0] <- "No"
AEDB$AlcoholUse[diet810 == 1] <- "Yes"
detach(AEDB)
# AEDB.temp <- subset(AEDB, select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "diet810", "AlcoholUse"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# AEDB.temp$AlcoholUse <- to_factor(AEDB.temp$AlcoholUse)
#
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
#
# rm(AEDB.temp)
3.2.2 Prepare baseline characteristics
We are interested in the following variables at baseline.
- Age (years)
- Female sex (N, %)
- Hypertension (N, %)
- SBP (mmHg)
- DBP (mmHg)
- Diabetes mellitus (N, %)
- Total cholesterol levels (mg/dL)
- LDL cholesterol levels (mg/dL)
- HDL cholesterol levels (mg/dL)
- Triglyceride levels (mg/dL)
- Use of statins (N, %)
- Use of antiplatelet drugs (N, %)
- BMI (kg/m²)
- Smoking status (N, %)
- Never smokers
- Ex-smokers
- Current smokers
- History of CAD (N, %)
- History of PAD (N, %)
- Clinical manifestations
- Asymptomatic
- Amaurosis fugax
- TIA
- Stroke
- eGFR (mL/min/1.73 m²)
- Testosterone (nmol/L)
cat("====================================================================================================\n")====================================================================================================cat("SELECTION THE SHIZZLE\n")SELECTION THE SHIZZLE### Artery levels
# AEdata$Artery_summary:
# value label
# NOT USE - 0 No artery known (yet), no surgery (patient ill, died, exited study), re-numbered to AAA
# USE - 1 carotid (left & right)
# USE - 2 femoral/iliac (left, right or both sides)
# NOT USE - 3 other carotid arteries (common, external)
# NOT USE - 4 carotid bypass and injury (left, right or both sides)
# NOT USE - 5 aneurysmata (carotid & femoral)
# NOT USE - 6 aorta
# NOT USE - 7 other arteries (renal, popliteal, vertebral)
# NOT USE - 8 femoral bypass, angioseal and injury (left, right or both sides)
### AEdata$informedconsent
# value label
# NOT USE - -999 missing
# NOT USE - 0 no, died
# USE - 1 yes
# USE - 2 yes, health treatment when possible
# USE - 3 yes, no health treatment
# USE - 4 yes, no health treatment, no commercial business
# NOT USE - 5 yes, no tissue, no commerical business
# NOT USE - 6 yes, no tissue, no questionnaires, no medical info, no commercial business
# USE - 7 yes, no questionnaires, no health treatment, no commercial business
# USE - 8 yes, no questionnaires, health treatment when possible
# NOT USE - 9 yes, no tissue, no questionnaires, no health treatment, no commerical business
# USE - 10 yes, no health treatment, no medical info, no commercial business
# NOT USE - 11 yes, no tissue, no questionnaires, no health treatment, no medical info, no commercial business
# USE - 12 yes, no questionnaires, no health treatment
# NOT USE - 13 yes, no tissue, no health treatment
# NOT USE - 14 yes, no tissue, no questionnaires
# NOT USE - 15 yes, no tissue, health treatment when possible
# NOT USE - 16 yes, no tissue
# USE - 17 yes, no commerical business
# USE - 18 yes, health treatment when possible, no commercial business
# USE - 19 yes, no medical info, no commercial business
# USE - 20 yes, no questionnaires
# NOT USE - 21 yes, no tissue, no questionnaires, no health treatment, no medical info
# NOT USE - 22 yes, no tissue, no questionnaires, no health treatment, no commercial business
# USE - 23 yes, no medical info
# USE - 24 yes, no questionnaires, no commercial business
# USE - 25 yes, no questionnaires, no health treatment, no medical info
# USE - 26 yes, no questionnaires, health treatment when possible, no commercial business
# USE - 27 yes, no health treatment, no medical info
# NOT USE - 28 no, doesn't want to
# NOT USE - 29 no, unable to sign
# NOT USE - 30 no, no reaction
# NOT USE - 31 no, lost
# NOT USE - 32 no, too old
# NOT USE - 34 yes, no medical info, health treatment when possible
# NOT USE - 35 no (never asked for IC because there was no tissue)
# USE - 36 yes, no medical info, no commercial business, health treatment when possible
# NOT USE - 37 no, endpoint
# USE - 38 wil niets invullen, wel alles gebruiken
# USE - 39 second informed concents: yes, no commercial business
# NOT USE - 40 nooit geincludeerd
cat("- sanity checking PRIOR to selection")- sanity checking PRIOR to selectionlibrary(data.table)
require(labelled)
ae.gender <- to_factor(AEDB$Gender)
ae.hospital <- to_factor(AEDB$Hospital)
table(ae.gender, ae.hospital, dnn = c("Sex", "Hospital")) Hospital
Sex St. Antonius, Nieuwegein UMC Utrecht
female 524 636
male 1211 1420ae.artery <- to_factor(AEDB$Artery_summary)
table(ae.artery, ae.gender, dnn = c("Sex", "Artery")) Artery
Sex female male
No artery known (yet), no surgery (patient ill, died, exited study), re-numbered to AAA 0 0
carotid (left & right) 805 1781
femoral/iliac (left, right or both sides) 320 796
other carotid arteries (common, external) 17 35
carotid bypass and injury (left, right or both sides) 6 3
aneurysmata (carotid & femoral) 1 0
aorta 3 5
other arteries (renal, popliteal, vertebral) 4 9
femoral bypass, angioseal and injury (left, right or both sides) 4 2rm(ae.gender, ae.hospital, ae.artery)
# I change numeric and factors manually because, well, I wouldn't know how to fix it otherwise
# to have this 'tibble' work with 'tableone'... :-)
AEDB$Age <- as.numeric(AEDB$Age)
AEDB$diastoli <- as.numeric(AEDB$diastoli)
AEDB$systolic <- as.numeric(AEDB$systolic)
AEDB$TC_finalCU <- as.numeric(AEDB$TC_finalCU)
AEDB$LDL_finalCU <- as.numeric(AEDB$LDL_finalCU)
AEDB$HDL_finalCU <- as.numeric(AEDB$HDL_finalCU)
AEDB$TG_finalCU <- as.numeric(AEDB$TG_finalCU)
AEDB$TC_final <- as.numeric(AEDB$TC_final)
AEDB$LDL_final <- as.numeric(AEDB$LDL_final)
AEDB$HDL_final <- as.numeric(AEDB$HDL_final)
AEDB$TG_final <- as.numeric(AEDB$TG_final)
AEDB$Age <- as.numeric(AEDB$Age)
AEDB$GFR_MDRD <- as.numeric(AEDB$GFR_MDRD)
AEDB$BMI <- as.numeric(AEDB$BMI)
AEDB$eCigarettes <- as.numeric(AEDB$eCigarettes)
AEDB$ePackYearsSmoking <- as.numeric(AEDB$ePackYearsSmoking)
AEDB$EP_composite_time <- as.numeric(AEDB$EP_composite_time)
AEDB$macmean0 <- as.numeric(AEDB$macmean0)
AEDB$smcmean0 <- as.numeric(AEDB$smcmean0)
AEDB$neutrophils <- as.numeric(AEDB$neutrophils)
AEDB$Mast_cells_plaque <- as.numeric(AEDB$Mast_cells_plaque)
AEDB$vessel_density_averaged <- as.numeric(AEDB$vessel_density_averaged)
require(labelled)
AEDB$ORyear <- to_factor(AEDB$ORyear)
AEDB$Gender <- to_factor(AEDB$Gender)
AEDB$Hospital <- to_factor(AEDB$Hospital)
AEDB$KDOQI <- to_factor(AEDB$KDOQI)
AEDB$BMI_WHO <- to_factor(AEDB$BMI_WHO)
AEDB$DiabetesStatus <- to_factor(AEDB$DiabetesStatus)
AEDB$SmokerStatus <- to_factor(AEDB$SmokerStatus)
AEDB$AlcoholUse <- to_factor(AEDB$AlcoholUse)
AEDB$Hypertension.selfreport <- to_factor(AEDB$Hypertension1)
AEDB$Hypertension.selfreportdrug <- to_factor(AEDB$Hypertension2)
AEDB$Hypertension.composite <- to_factor(AEDB$Hypertension.composite)
AEDB$Hypertension.drugs <- to_factor(AEDB$Hypertension.drugs)
AEDB$Med.anticoagulants <- to_factor(AEDB$Med.anticoagulants)
AEDB$Med.all.antiplatelet <- to_factor(AEDB$Med.all.antiplatelet)
AEDB$Med.Statin.LLD <- to_factor(AEDB$Med.Statin.LLD)
AEDB$Stroke_Dx <- to_factor(AEDB$Stroke_Dx)
AEDB$CAD_history <- to_factor(AEDB$CAD_history)
AEDB$PAOD <- to_factor(AEDB$PAOD)
AEDB$Peripheral.interv <- to_factor(AEDB$Peripheral.interv)
AEDB$sympt <- to_factor(AEDB$sympt)
AEDB$Symptoms.3g <- to_factor(AEDB$Symptoms.3g)
AEDB$Symptoms.4g <- to_factor(AEDB$Symptoms.4g)
AEDB$Symptoms.5G <- to_factor(AEDB$Symptoms.5G)
AEDB$AsymptSympt <- to_factor(AEDB$AsymptSympt)
AEDB$AsymptSympt2G <- to_factor(AEDB$AsymptSympt2G)
AEDB$restenos <- to_factor(AEDB$restenos)
AEDB$stenose <- to_factor(AEDB$stenose)
AEDB$EP_composite <- to_factor(AEDB$EP_composite)
AEDB$Macrophages.bin <- to_factor(AEDB$Macrophages.bin)
AEDB$SMC.bin <- to_factor(AEDB$SMC.bin)
AEDB$IPH.bin <- to_factor(AEDB$IPH.bin)
AEDB$Calc.bin <- to_factor(AEDB$Calc.bin)
AEDB$Collagen.bin <- to_factor(AEDB$Collagen.bin)
AEDB$Fat.bin_10 <- to_factor(AEDB$Fat.bin_10)
AEDB$Fat.bin_40 <- to_factor(AEDB$Fat.bin_40)
AEDB$OverallPlaquePhenotype <- to_factor(AEDB$OverallPlaquePhenotype)
AEDB$Artery_summary <- to_factor(AEDB$Artery_summary)
AEDB$informedconsent <- to_factor(AEDB$informedconsent)
AEDB.CEA <- subset(AEDB,
(Artery_summary == "carotid (left & right)" | Artery_summary == "other carotid arteries (common, external)") & # we only want carotids
informedconsent != "missing" & # we are really strict in selecting based on 'informed consent'!
informedconsent != "no, died" &
informedconsent != "yes, no tissue, no commerical business" &
informedconsent != "yes, no tissue, no questionnaires, no medical info, no commercial business" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commerical business" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info, no commercial business" &
informedconsent != "yes, no tissue, no health treatment" &
informedconsent != "yes, no tissue, no questionnaires" &
informedconsent != "yes, no tissue, health treatment when possible" &
informedconsent != "yes, no tissue" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commercial business" &
informedconsent != "no, doesn't want to" &
informedconsent != "no, unable to sign" &
informedconsent != "no, no reaction" &
informedconsent != "no, lost" &
informedconsent != "no, too old" &
informedconsent != "yes, no medical info, health treatment when possible" &
informedconsent != "no (never asked for IC because there was no tissue)" &
informedconsent != "no, endpoint" &
informedconsent != "nooit geincludeerd" &
!is.na(AsymptSympt2G))
# AEDB.CEA[1:10, 1:10]
dim(AEDB.CEA)[1] 2421 1100cat("===========================================================================================\n")===========================================================================================cat("CREATE BASELINE TABLE\n")CREATE BASELINE TABLE# Baseline table variables
basetable_vars = c("Hospital", "ORyear",
"Age", "Gender",
"TC_finalCU", "LDL_finalCU", "HDL_finalCU", "TG_finalCU",
"TC_final", "LDL_final", "HDL_final", "TG_final",
"systolic", "diastoli", "GFR_MDRD", "BMI",
"KDOQI", "BMI_WHO",
"SmokerStatus", "AlcoholUse",
"DiabetesStatus",
"Hypertension.selfreport", "Hypertension.selfreportdrug", "Hypertension.composite", "Hypertension.drugs",
"Med.anticoagulants", "Med.all.antiplatelet", "Med.Statin.LLD",
"Stroke_Dx", "sympt", "Symptoms.5G", "AsymptSympt", "AsymptSympt2G",
"restenos", "stenose",
"CAD_history", "PAOD", "Peripheral.interv",
"EP_composite", "EP_composite_time",
"macmean0", "smcmean0", "Macrophages.bin", "SMC.bin",
"neutrophils", "Mast_cells_plaque",
"IPH.bin", "vessel_density_averaged",
"Calc.bin", "Collagen.bin",
"Fat.bin_10", "Fat.bin_40", "OverallPlaquePhenotype")
basetable_bin = c("Gender",
"KDOQI", "BMI_WHO",
"SmokerStatus", "AlcoholUse",
"DiabetesStatus",
"Hypertension.selfreport", "Hypertension.selfreportdrug", "Hypertension.composite", "Hypertension.drugs",
"Med.anticoagulants", "Med.all.antiplatelet", "Med.Statin.LLD",
"Stroke_Dx", "sympt", "Symptoms.5G", "AsymptSympt", "AsymptSympt2G",
"restenos", "stenose",
"CAD_history", "PAOD", "Peripheral.interv",
"EP_composite", "Macrophages.bin", "SMC.bin",
"IPH.bin",
"Calc.bin", "Collagen.bin",
"Fat.bin_10", "Fat.bin_40", "OverallPlaquePhenotype")
# basetable_bin
basetable_con = basetable_vars[!basetable_vars %in% basetable_bin]
# basetable_con3.2.3 Athero-Express Biobank Study: baseline characteristics
Showing the baseline table of the whole Athero-Express Biobank.
# Create baseline tables
# http://rstudio-pubs-static.s3.amazonaws.com/13321_da314633db924dc78986a850813a50d5.html
AEDB.CEA.tableOne = print(CreateTableOne(vars = basetable_vars,
# factorVars = basetable_bin,
# strata = "Gender",
data = AEDB.CEA, includeNA = TRUE),
nonnormal = c(), missing = TRUE,
quote = FALSE, noSpaces = FALSE, showAllLevels = TRUE, explain = TRUE,
format = "pf",
contDigits = 3)[,1:3]
level Overall
n 2421
Hospital % (freq) St. Antonius, Nieuwegein 39.2 ( 948)
UMC Utrecht 60.8 (1473)
ORyear % (freq) No data available/missing 0.0 ( 0)
2002 3.3 ( 81)
2003 6.5 ( 157)
2004 7.8 ( 190)
2005 7.6 ( 185)
2006 7.6 ( 183)
2007 6.3 ( 152)
2008 5.7 ( 138)
2009 7.5 ( 181)
2010 6.6 ( 159)
2011 6.7 ( 163)
2012 7.3 ( 176)
2013 6.2 ( 149)
2014 6.7 ( 163)
2015 3.1 ( 76)
2016 3.5 ( 85)
2017 2.7 ( 65)
2018 2.7 ( 66)
2019 2.1 ( 52)
Age (mean (SD)) 69.105 (9.302)
Gender % (freq) female 30.5 ( 738)
male 69.5 (1683)
TC_finalCU (mean (SD)) 184.803 (56.262)
LDL_finalCU (mean (SD)) 108.420 (41.744)
HDL_finalCU (mean (SD)) 46.435 (17.005)
TG_finalCU (mean (SD)) 151.216 (91.277)
TC_final (mean (SD)) 4.786 (1.457)
LDL_final (mean (SD)) 2.808 (1.081)
HDL_final (mean (SD)) 1.203 (0.440)
TG_final (mean (SD)) 1.709 (1.031)
systolic (mean (SD)) 152.419 (25.166)
diastoli (mean (SD)) 81.318 (25.188)
GFR_MDRD (mean (SD)) 73.121 (21.152)
BMI (mean (SD)) 26.488 (3.977)
KDOQI % (freq) No data available/missing 0.0 ( 0)
Normal kidney function 19.1 ( 462)
CKD 2 (Mild) 50.9 (1232)
CKD 3 (Moderate) 22.8 ( 553)
CKD 4 (Severe) 1.3 ( 32)
CKD 5 (Failure) 0.4 ( 10)
<NA> 5.5 ( 132)
BMI_WHO % (freq) No data available/missing 0.0 ( 0)
Underweight 1.0 ( 24)
Normal 35.1 ( 850)
Overweight 43.4 (1051)
Obese 14.5 ( 352)
<NA> 5.9 ( 144)
SmokerStatus % (freq) Current smoker 33.2 ( 803)
Ex-smoker 48.0 (1163)
Never smoked 12.9 ( 313)
<NA> 5.9 ( 142)
AlcoholUse % (freq) No 34.5 ( 835)
Yes 61.5 (1488)
<NA> 4.0 ( 98)
DiabetesStatus % (freq) Control (no Diabetes Dx/Med) 75.2 (1820)
Diabetes 23.7 ( 574)
<NA> 1.1 ( 27)
Hypertension.selfreport % (freq) No data available/missing 0.0 ( 0)
no 24.3 ( 589)
yes 72.4 (1754)
<NA> 3.2 ( 78)
Hypertension.selfreportdrug % (freq) No data available/missing 0.0 ( 0)
no 29.9 ( 725)
yes 65.6 (1589)
<NA> 4.4 ( 107)
Hypertension.composite % (freq) No data available/missing 0.0 ( 0)
no 14.6 ( 353)
yes 84.3 (2040)
<NA> 1.2 ( 28)
Hypertension.drugs % (freq) No data available/missing 0.0 ( 0)
no 23.3 ( 565)
yes 75.3 (1823)
<NA> 1.4 ( 33)
Med.anticoagulants % (freq) No data available/missing 0.0 ( 0)
no 87.3 (2114)
yes 11.1 ( 269)
<NA> 1.6 ( 38)
Med.all.antiplatelet % (freq) No data available/missing 0.0 ( 0)
no 12.2 ( 295)
yes 86.3 (2090)
<NA> 1.5 ( 36)
Med.Statin.LLD % (freq) No data available/missing 0.0 ( 0)
no 20.3 ( 491)
yes 78.3 (1896)
<NA> 1.4 ( 34)
Stroke_Dx % (freq) Missing 0.0 ( 0)
No stroke diagnosed 71.5 (1731)
Stroke diagnosed 21.6 ( 524)
<NA> 6.9 ( 166)
sympt % (freq) missing 0.0 ( 0)
Asymptomatic 11.2 ( 270)
TIA 39.7 ( 961)
minor stroke 16.8 ( 407)
Major stroke 9.8 ( 238)
Amaurosis fugax 15.7 ( 379)
Four vessel disease 1.6 ( 38)
Vertebrobasilary TIA 0.2 ( 5)
Retinal infarction 1.4 ( 34)
Symptomatic, but aspecific symtoms 2.2 ( 53)
Contralateral symptomatic occlusion 0.5 ( 11)
retinal infarction 0.2 ( 6)
armclaudication due to occlusion subclavian artery, CEA needed for bypass 0.0 ( 1)
retinal infarction + TIAs 0.0 ( 0)
Ocular ischemic syndrome 0.7 ( 16)
ischemisch glaucoom 0.0 ( 0)
subclavian steal syndrome 0.1 ( 2)
TGA 0.0 ( 0)
Symptoms.5G % (freq) Asymptomatic 11.2 ( 270)
Ocular 16.3 ( 395)
Other 4.3 ( 105)
Retinal infarction 1.7 ( 40)
Stroke 26.6 ( 645)
TIA 39.9 ( 966)
AsymptSympt % (freq) Asymptomatic 11.2 ( 270)
Ocular and others 22.3 ( 540)
Symptomatic 66.5 (1611)
AsymptSympt2G % (freq) Asymptomatic 11.2 ( 270)
Symptomatic 88.8 (2151)
restenos % (freq) missing 0.0 ( 0)
de novo 93.7 (2268)
restenosis 4.9 ( 118)
stenose bij angioseal na PTCA 0.0 ( 0)
<NA> 1.4 ( 35)
stenose % (freq) missing 0.0 ( 0)
0-49% 0.5 ( 13)
50-70% 7.8 ( 189)
70-90% 46.6 (1127)
90-99% 38.3 ( 927)
100% (Occlusion) 1.3 ( 31)
NA 0.0 ( 1)
50-99% 0.6 ( 15)
70-99% 2.8 ( 68)
99 0.1 ( 2)
<NA> 2.0 ( 48)
CAD_history % (freq) Missing 0.0 ( 0)
No history CAD 66.8 (1618)
History CAD 31.2 ( 756)
<NA> 1.9 ( 47)
PAOD % (freq) missing/no data 0.0 ( 0)
no 77.5 (1876)
yes 20.5 ( 497)
<NA> 2.0 ( 48)
Peripheral.interv % (freq) no 77.2 (1868)
yes 19.9 ( 482)
<NA> 2.9 ( 71)
EP_composite % (freq) No data available. 0.0 ( 0)
No composite endpoints 70.6 (1709)
Composite endpoints 24.4 ( 590)
<NA> 5.0 ( 122)
EP_composite_time (mean (SD)) 2.479 (1.109)
macmean0 (mean (SD)) 0.768 (1.184)
smcmean0 (mean (SD)) 1.985 (2.381)
Macrophages.bin % (freq) no/minor 34.9 ( 846)
moderate/heavy 40.9 ( 991)
<NA> 24.1 ( 584)
SMC.bin % (freq) no/minor 24.9 ( 602)
moderate/heavy 51.3 (1242)
<NA> 23.8 ( 577)
neutrophils (mean (SD)) 147.151 (419.998)
Mast_cells_plaque (mean (SD)) 164.488 (163.771)
IPH.bin % (freq) no 30.7 ( 744)
yes 45.8 (1108)
<NA> 23.5 ( 569)
vessel_density_averaged (mean (SD)) 8.318 (6.388)
Calc.bin % (freq) no/minor 41.6 (1006)
moderate/heavy 35.1 ( 849)
<NA> 23.4 ( 566)
Collagen.bin % (freq) no/minor 15.8 ( 382)
moderate/heavy 60.6 (1467)
<NA> 23.6 ( 572)
Fat.bin_10 % (freq) <10% 22.4 ( 542)
>10% 54.3 (1314)
<NA> 23.3 ( 565)
Fat.bin_40 % (freq) <40% 56.2 (1360)
>40% 20.5 ( 496)
<NA> 23.3 ( 565)
OverallPlaquePhenotype % (freq) atheromatous 19.8 ( 480)
fibroatheromatous 27.8 ( 672)
fibrous 28.7 ( 695)
<NA> 23.7 ( 574)
Missing
n
Hospital % (freq) 0.0
ORyear % (freq) 0.0
Age (mean (SD)) 0.0
Gender % (freq) 0.0
TC_finalCU (mean (SD)) 38.0
LDL_finalCU (mean (SD)) 45.6
HDL_finalCU (mean (SD)) 41.7
TG_finalCU (mean (SD)) 42.8
TC_final (mean (SD)) 38.0
LDL_final (mean (SD)) 45.6
HDL_final (mean (SD)) 41.7
TG_final (mean (SD)) 42.8
systolic (mean (SD)) 11.3
diastoli (mean (SD)) 11.3
GFR_MDRD (mean (SD)) 5.4
BMI (mean (SD)) 5.9
KDOQI % (freq) 5.5
BMI_WHO % (freq) 5.9
SmokerStatus % (freq) 5.9
AlcoholUse % (freq) 4.0
DiabetesStatus % (freq) 1.1
Hypertension.selfreport % (freq) 3.2
Hypertension.selfreportdrug % (freq) 4.4
Hypertension.composite % (freq) 1.2
Hypertension.drugs % (freq) 1.4
Med.anticoagulants % (freq) 1.6
Med.all.antiplatelet % (freq) 1.5
Med.Statin.LLD % (freq) 1.4
Stroke_Dx % (freq) 6.9
sympt % (freq) 0.0
Symptoms.5G % (freq) 0.0
AsymptSympt % (freq) 0.0
AsymptSympt2G % (freq) 0.0
restenos % (freq) 1.4
stenose % (freq) 2.0
CAD_history % (freq) 1.9
PAOD % (freq) 2.0
Peripheral.interv % (freq) 2.9
EP_composite % (freq) 5.0
EP_composite_time (mean (SD)) 5.2
macmean0 (mean (SD)) 29.7
smcmean0 (mean (SD)) 29.9
Macrophages.bin % (freq) 24.1
SMC.bin % (freq) 23.8
neutrophils (mean (SD)) 87.4
Mast_cells_plaque (mean (SD)) 90.0
IPH.bin % (freq) 23.5
vessel_density_averaged (mean (SD)) 35.1
Calc.bin % (freq) 23.4
Collagen.bin % (freq) 23.6
Fat.bin_10 % (freq) 23.3
Fat.bin_40 % (freq) 23.3
OverallPlaquePhenotype % (freq) 23.7
3.3 AESCRNA: baseline characteristics
metadata <- scRNAseqData@meta.data %>% as_tibble() %>% separate(orig.ident, c("Patient", NA))
scRNAseqDataMeta <- metadata %>% distinct(Patient, .keep_all = TRUE)distinct: removed 6,153 rows (99%), 38 rows remainingscRNAseqDataMetaAE <- merge(scRNAseqDataMeta, AEDB, by.x = "Patient", by.y = "STUDY_NUMBER", sort = FALSE, all.x = TRUE)
dim(scRNAseqDataMetaAE)[1] 38 1112# Replace missing data
# Ref: https://cran.r-project.org/web/packages/naniar/vignettes/replace-with-na.html
require(naniar)
na_strings <- c("NA", "N A", "N / A", "N/A", "N/ A",
"Not Available", "Not available",
"missing",
"-999", "-99",
"No data available/missing", "No data available/Missing")
# Then you write ~.x %in% na_strings - which reads as “does this value occur in the list of NA strings”.
scRNAseqDataMetaAE %>%
replace_with_na_all(condition = ~.x %in% na_strings)
cat("====================================================================================================")====================================================================================================cat("SELECTION THE SHIZZLE")SELECTION THE SHIZZLEcat("- sanity checking PRIOR to selection")- sanity checking PRIOR to selectionlibrary(data.table)
require(labelled)
ae.gender <- to_factor(scRNAseqDataMetaAE$Gender)
ae.hospital <- to_factor(scRNAseqDataMetaAE$Hospital)
table(ae.gender, ae.hospital, dnn = c("Sex", "Hospital"), useNA = "ifany") Hospital
Sex St. Antonius, Nieuwegein UMC Utrecht <NA>
female 0 10 0
male 0 26 0
<NA> 0 0 2ae.artery <- to_factor(scRNAseqDataMetaAE$Artery_summary)
table(ae.artery, ae.gender, dnn = c("Sex", "Artery"), useNA = "ifany") Artery
Sex female male <NA>
No artery known (yet), no surgery (patient ill, died, exited study), re-numbered to AAA 0 0 0
carotid (left & right) 10 25 0
femoral/iliac (left, right or both sides) 0 0 0
other carotid arteries (common, external) 0 1 0
carotid bypass and injury (left, right or both sides) 0 0 0
aneurysmata (carotid & femoral) 0 0 0
aorta 0 0 0
other arteries (renal, popliteal, vertebral) 0 0 0
femoral bypass, angioseal and injury (left, right or both sides) 0 0 0
<NA> 0 0 2ae.ic <- to_factor(scRNAseqDataMetaAE$informedconsent)
table(ae.ic, ae.gender, useNA = "ifany") ae.gender
ae.ic female male <NA>
missing 0 0 0
no, died 0 0 0
yes 5 14 0
yes, health treatment when possible 2 7 0
yes, no health treatment 1 2 0
yes, no health treatment, no commercial business 1 2 0
yes, no tissue, no commerical business 0 0 0
yes, no tissue, no questionnaires, no medical info, no commercial business 0 0 0
yes, no questionnaires, no health treatment, no commercial business 0 0 0
yes, no questionnaires, health treatment when possible 0 0 0
yes, no tissue, no questionnaires, no health treatment, no commerical business 0 0 0
yes, no health treatment, no medical info, no commercial business 0 0 0
yes, no tissue, no questionnaires, no health treatment, no medical info, no commercial business 0 0 0
yes, no questionnaires, no health treatment 0 0 0
yes, no tissue, no health treatment 0 0 0
yes, no tissue, no questionnaires 0 0 0
yes, no tissue, health treatment when possible 0 0 0
yes, no tissue 0 0 0
yes, no commerical business 0 1 0
yes, health treatment when possible, no commercial business 0 0 0
yes, no medical info, no commercial business 0 0 0
yes, no questionnaires 0 0 0
yes, no tissue, no questionnaires, no health treatment, no medical info 0 0 0
yes, no tissue, no questionnaires, no health treatment, no commercial business 0 0 0
yes, no medical info 0 0 0
yes, no questionnaires, no commercial business 0 0 0
yes, no questionnaires, no health treatment, no medical info 0 0 0
yes, no questionnaires, health treatment when possible, no commercial business 0 0 0
yes, no health treatment, no medical info 0 0 0
no, doesn't want to 0 0 0
no, unable to sign 0 0 0
no, no reaction 0 0 0
no, lost 0 0 0
no, too old 0 0 0
yes, no medical info, health treatment when possible 1 0 0
no (never asked for IC because there was no tissue) 0 0 0
yes, no medical info, no commercial business, health treatment when possible 0 0 0
no, endpoint 0 0 0
wil niets invullen, wel alles gebruiken 0 0 0
second informed concents: yes, no commercial business 0 0 0
nooit geincludeerd 0 0 0
<NA> 0 0 2rm(ae.gender, ae.hospital, ae.artery, ae.ic)
scRNAseqDataMetaAE.all <- subset(scRNAseqDataMetaAE,
(Artery_summary == "carotid (left & right)" | Artery_summary == "other carotid arteries (common, external)" ) & # we only want carotids
informedconsent != "missing" & # we are really strict in selecting based on 'informed consent'!
informedconsent != "no, died" &
informedconsent != "yes, no tissue, no commerical business" &
informedconsent != "yes, no tissue, no questionnaires, no medical info, no commercial business" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commerical business" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info, no commercial business" &
informedconsent != "yes, no tissue, no health treatment" &
informedconsent != "yes, no tissue, no questionnaires" &
informedconsent != "yes, no tissue, health treatment when possible" &
informedconsent != "yes, no tissue" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info" &
informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commercial business" &
informedconsent != "no, doesn't want to" &
informedconsent != "no, unable to sign" &
informedconsent != "no, no reaction" &
informedconsent != "no, lost" &
informedconsent != "no, too old" &
informedconsent != "yes, no medical info, health treatment when possible" &
informedconsent != "no (never asked for IC because there was no tissue)" &
informedconsent != "no, endpoint" &
informedconsent != "nooit geincludeerd")
# scRNAseqDataMetaAE.all[1:10, 1:10]
dim(scRNAseqDataMetaAE.all)[1] 35 1112# DT::datatable(scRNAseqDataMetaAE.all)
Showing the baseline table.
cat("===========================================================================================")===========================================================================================cat("CREATE BASELINE TABLE")CREATE BASELINE TABLE# Create baseline tables
# http://rstudio-pubs-static.s3.amazonaws.com/13321_da314633db924dc78986a850813a50d5.html
scRNAseqDataMetaAE.all.tableOne = print(CreateTableOne(vars = basetable_vars,
# factorVars = basetable_bin,
# strata = "Gender",
data = scRNAseqDataMetaAE.all, includeNA = TRUE),
nonnormal = c(),
quote = FALSE, showAllLevels = TRUE,
format = "p",
contDigits = 3)[,1:2]Warning in ModuleReturnVarsExist(vars, data) :
These variables only have NA/NaN: macmean0 smcmean0 Macrophages.bin SMC.bin neutrophils Mast_cells_plaque IPH.bin vessel_density_averaged Calc.bin Collagen.bin Fat.bin_10 Fat.bin_40 OverallPlaquePhenotype Dropped
level Overall
n 35
Hospital (%) St. Antonius, Nieuwegein 0.0
UMC Utrecht 100.0
ORyear (%) No data available/missing 0.0
2002 0.0
2003 0.0
2004 0.0
2005 0.0
2006 0.0
2007 0.0
2008 0.0
2009 0.0
2010 0.0
2011 0.0
2012 0.0
2013 0.0
2014 0.0
2015 0.0
2016 0.0
2017 0.0
2018 65.7
2019 34.3
Age (mean (SD)) 72.743 (8.176)
Gender (%) female 25.7
male 74.3
TC_finalCU (mean (SD)) 168.311 (47.773)
LDL_finalCU (mean (SD)) 96.971 (38.196)
HDL_finalCU (mean (SD)) 43.897 (10.171)
TG_finalCU (mean (SD)) 171.469 (109.939)
TC_final (mean (SD)) 4.359 (1.237)
LDL_final (mean (SD)) 2.512 (0.989)
HDL_final (mean (SD)) 1.137 (0.263)
TG_final (mean (SD)) 1.938 (1.242)
systolic (mean (SD)) 153.265 (25.803)
diastoli (mean (SD)) 80.824 (16.129)
GFR_MDRD (mean (SD)) 83.278 (31.136)
BMI (mean (SD)) 26.477 (3.428)
KDOQI (%) No data available/missing 0.0
Normal kidney function 34.3
CKD 2 (Mild) 31.4
CKD 3 (Moderate) 22.9
CKD 4 (Severe) 0.0
CKD 5 (Failure) 0.0
<NA> 11.4
BMI_WHO (%) No data available/missing 0.0
Underweight 2.9
Normal 31.4
Overweight 42.9
Obese 14.3
<NA> 8.6
SmokerStatus (%) Current smoker 34.3
Ex-smoker 48.6
Never smoked 14.3
<NA> 2.9
AlcoholUse (%) No 37.1
Yes 57.1
<NA> 5.7
DiabetesStatus (%) Control (no Diabetes Dx/Med) 62.9
Diabetes 37.1
Hypertension.selfreport (%) No data available/missing 0.0
no 11.4
yes 85.7
<NA> 2.9
Hypertension.selfreportdrug (%) No data available/missing 0.0
no 11.4
yes 85.7
<NA> 2.9
Hypertension.composite (%) No data available/missing 0.0
no 5.7
yes 94.3
Hypertension.drugs (%) No data available/missing 0.0
no 5.7
yes 91.4
<NA> 2.9
Med.anticoagulants (%) No data available/missing 0.0
no 88.6
yes 5.7
<NA> 5.7
Med.all.antiplatelet (%) No data available/missing 0.0
no 25.7
yes 71.4
<NA> 2.9
Med.Statin.LLD (%) No data available/missing 0.0
no 20.0
yes 77.1
<NA> 2.9
Stroke_Dx (%) Missing 0.0
No stroke diagnosed 51.4
Stroke diagnosed 48.6
sympt (%) missing 0.0
Asymptomatic 17.1
TIA 14.3
minor stroke 34.3
Major stroke 8.6
Amaurosis fugax 14.3
Four vessel disease 0.0
Vertebrobasilary TIA 0.0
Retinal infarction 2.9
Symptomatic, but aspecific symtoms 0.0
Contralateral symptomatic occlusion 0.0
retinal infarction 2.9
armclaudication due to occlusion subclavian artery, CEA needed for bypass 0.0
retinal infarction + TIAs 0.0
Ocular ischemic syndrome 5.7
ischemisch glaucoom 0.0
subclavian steal syndrome 0.0
TGA 0.0
Symptoms.5G (%) Asymptomatic 17.1
Ocular 20.0
Other 0.0
Retinal infarction 5.7
Stroke 42.9
TIA 14.3
AsymptSympt (%) Asymptomatic 17.1
Ocular and others 25.7
Symptomatic 57.1
AsymptSympt2G (%) Asymptomatic 17.1
Symptomatic 82.9
restenos (%) missing 0.0
de novo 100.0
restenosis 0.0
stenose bij angioseal na PTCA 0.0
stenose (%) missing 0.0
0-49% 2.9
50-70% 17.1
70-90% 42.9
90-99% 17.1
100% (Occlusion) 0.0
NA 0.0
50-99% 0.0
70-99% 20.0
99 0.0
CAD_history (%) Missing 0.0
No history CAD 74.3
History CAD 25.7
PAOD (%) missing/no data 0.0
no 85.7
yes 14.3
Peripheral.interv (%) no 77.1
yes 20.0
<NA> 2.9
EP_composite (%) No data available. 0.0
No composite endpoints 42.9
Composite endpoints 11.4
<NA> 45.7
EP_composite_time (mean (SD)) 0.931 (0.483) Writing the baseline table to Excel format.
# Write basetable
require(openxlsx)
write.xlsx(file = paste0(OUT_loc, "/",Today,".",PROJECTNAME,".AE.BaselineTable.scRNAseq.xlsx"),
format(scRNAseqDataMetaAE.all.tableOne, digits = 5, scientific = FALSE) , rowNames = TRUE, colNames = TRUE)
4 AESCRNA
4.1 Quality control
Here review the number of cells per sample, plate, and patients. And plot the ratio’s per sample and study number.
## check stuff
cat("\nHow many cells per type ...?")
How many cells per type ...?sort(table(scRNAseqData@meta.data$SCT_snn_res.0.8))
17 16 15 14 13 12 11 10 9 8 7 6 5 4 3 2 1 0
31 34 84 110 151 172 190 203 211 225 290 345 437 534 577 626 861 1110 # cat("\n\nHow many cells per plate ...?")
# sort(table(scRNAseqData@meta.data$ID))
# cat("\n\nHow many cells per type per plate ...?")
# table(scRNAseqData@meta.data$SCT_snn_res.0.8, scRNAseqData@meta.data$ID)
cat("\n\nHow many cells per patient ...?")
How many cells per patient ...?sort(table(scRNAseqData@meta.data$Patient))integer(0)cat("\n\nVisualizing these ratio's per study number and sample ...?")
Visualizing these ratio's per study number and sample ...?UMAPPlot(scRNAseqData, label = TRUE, pt.size = 1.25, label.size = 4, group.by = "ident",
repel = TRUE)
ggsave(paste0(PLOT_loc, "/", Today, ".UMAP.png"), plot = last_plot())Saving 7.29 x 4.51 in imageggsave(paste0(PLOT_loc, "/", Today, ".UMAP.ps"), plot = last_plot())Saving 7.29 x 4.51 in image
# barplot(prop.table(x = table(scRNAseqData@active.ident, scRNAseqData@meta.data$Patient)),
# cex.axis = 1.0, cex.names = 0.5, las = 1,
# col = uithof_color, xlab = "study number", legend.text = FALSE, args.legend = list(x = "bottom"))
# dev.copy(pdf, paste0(QC_loc, "/", Today, ".cell_ratios_per_sample.pdf"))
# dev.off()
# barplot(prop.table(x = table(scRNAseqData@active.ident, scRNAseqData@meta.data$ID)),
# cex.axis = 1.0, cex.names = 0.5, las = 2,
# col = uithof_color, xlab = "sample ID", legend.text = FALSE, args.legend = list(x = "bottom"))
# dev.copy(pdf, paste0(QC_loc, "/", Today, ".cell_ratios_per_sample_per_plate.pdf"))
# dev.off()
4.2 Visualisations
Let’s project known cellular markers.
UMAPPlot(scRNAseqData, label = FALSE, pt.size = 1.25, label.size = 4, group.by = "ident",
repel = TRUE)
# endothelial cells
FeaturePlot(scRNAseqData, features = c("CD34"), cols = c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("EDN1"), cols = c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("EDNRA", "EDNRB"), cols = c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("CDH5", "PECAM1"), cols = c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("ACKR1"), cols = c("#ECECEC", "#DB003F"))
# SMC
FeaturePlot(scRNAseqData, features = c("MYH11"), cols = c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("LGALS3", "ACTA2"), cols = c("#ECECEC", "#DB003F"))
# macrophages
FeaturePlot(scRNAseqData, features = c("CD14", "CD68"), cols = c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("CD36"), cols = c("#ECECEC", "#DB003F"))
# t-cells
FeaturePlot(scRNAseqData, features = c("CD3E"), cols = c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("CD4"), cols = c("#ECECEC", "#DB003F"))
# FeaturePlot(scRNAseqData, features = c("CD8"), cols = c("#ECECEC", "#DB003F"))
# b-cells
FeaturePlot(scRNAseqData, features = c("CD79A"), cols = c("#ECECEC", "#DB003F"))
# mast cells
FeaturePlot(scRNAseqData, features = c("KIT"), cols = c("#ECECEC", "#DB003F"))
# NK cells
FeaturePlot(scRNAseqData, features = c("NCAM1"), cols = c("#ECECEC", "#DB003F"))
4.3 Targets of interest:
We check whether the targets genes, C6orf195, EDN1, PHACTR1, TBC1D7, GFOD1, ENPP1, ENPP3, IGFBP3, AC011294.3, MTAP, RP11-145E5.5, C9orf53, CDKN2A, CDKN2B, ZNF485, ZNF32, AL137026.1, ARID5B, RTKN2, CAMK2G, VCL, AP3M1, ADK, KAT6B, DUPD1, DUSP13, SAMD8, VDAC2, COMTD1, FGF23, COL4A1, COL4A2, CHRNA5, CHRNB4, ADAMTS7, MORF4L1, CTSH, BCAM, PVRL2, TOMM40, APOE, APOC1, were sequenced using our method (STARseq).
Several genes are not present or have different names, these are listed here, and were manually removed from/changed in the list.
- AC011294.3 ==> not found
- C6orf195 => LINC01600 replacement, not found
- C9orf53 => CDKN2A-DT replacement, not found
- AL137026.1 ==> not found
- DUPD1 => DUSP29 replacement, not found
- RP11-145E5.5 ==> not found
- PVRL2 => NECTIN2 replacement
- KIAA1462 => JCAD replacement
- ZNF32 ==> not found
- BCAM ==> not found
target_genes [1] "C6orf195" "EDN1" "PHACTR1" "TBC1D7" "GFOD1" "ENPP1" "ENPP3" "IGFBP3"
[9] "AC011294.3" "MTAP" "RP11-145E5.5" "C9orf53" "CDKN2A" "CDKN2B" "ZNF485" "ZNF32"
[17] "AL137026.1" "ARID5B" "RTKN2" "CAMK2G" "VCL" "AP3M1" "ADK" "KAT6B"
[25] "DUPD1" "DUSP13" "SAMD8" "VDAC2" "COMTD1" "FGF23" "COL4A1" "COL4A2"
[33] "CHRNA5" "CHRNB4" "ADAMTS7" "MORF4L1" "CTSH" "BCAM" "PVRL2" "TOMM40"
[41] "APOE" "APOC1" 4.3.1 Expression in cell communities
target_genes_rm <- c("AC011294.3", "C6orf195", "C9orf53", "AL137026.1", "DUPD1", "RP11-145E5.5", "PVRL2",
"RP1-257A7.4", "RP1-257A7.5", "KIAA1462",
"ZNF32", "BCAM")
temp = target_genes[!target_genes %in% target_genes_rm]
target_genes_qc <- c(temp, "NECTIN2", "JCAD")
target_genes_qc [1] "EDN1" "PHACTR1" "TBC1D7" "GFOD1" "ENPP1" "ENPP3" "IGFBP3" "MTAP" "CDKN2A" "CDKN2B" "ZNF485" "ARID5B" "RTKN2"
[14] "CAMK2G" "VCL" "AP3M1" "ADK" "KAT6B" "DUSP13" "SAMD8" "VDAC2" "COMTD1" "FGF23" "COL4A1" "COL4A2" "CHRNA5"
[27] "CHRNB4" "ADAMTS7" "MORF4L1" "CTSH" "TOMM40" "APOE" "APOC1" "NECTIN2" "JCAD" library(RColorBrewer)
p1 <- DotPlot(scRNAseqData, features = target_genes_qc,
cols = "RdBu")
p1 + theme(axis.text.x = element_text(angle = 45, hjust=1, size = 5))
ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.Targets.png"), plot = last_plot())Saving 7.29 x 4.51 in imageggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.Targets.ps"), plot = last_plot())Saving 7.29 x 4.51 in image
rm(p1)
# FeaturePlot(scRNAseqData, features = c(target_genes_qc),
# cols = c("#ECECEC", "#DB003F", "#9A3480","#1290D9"),
# combine = TRUE)
#
# ggsave(paste0(PLOT_loc, "/", Today, ".FeaturePlot.Targets.png"), plot = last_plot())
# ggsave(paste0(PLOT_loc, "/", Today, ".FeaturePlot.Targets.ps"), plot = last_plot())
# VlnPlot(scRNAseqData, features = "DUSP29")
for (GENE in target_genes_qc){
print(paste0("Projecting the expression of ", GENE, "."))
vp1 <- VlnPlot(scRNAseqData, features = GENE) +
xlab("cell communities") +
ylab(bquote("normalized expression")) +
theme(axis.title.x = element_text(color = "#000000", size = 14, face = "bold"),
axis.title.y = element_text(color = "#000000", size = 14, face = "bold"),
legend.position = "none")
ggsave(paste0(PLOT_loc, "/", Today, ".VlnPlot.",GENE,".png"), plot = last_plot())
ggsave(paste0(PLOT_loc, "/", Today, ".VlnPlot.",GENE,".ps"), plot = last_plot())
# print(vp1)
}[1] "Projecting the expression of EDN1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of PHACTR1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of TBC1D7."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of GFOD1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of ENPP1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of ENPP3."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of IGFBP3."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of MTAP."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of CDKN2A."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of CDKN2B."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of ZNF485."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of ARID5B."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of RTKN2."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of CAMK2G."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of VCL."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of AP3M1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of ADK."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of KAT6B."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of DUSP13."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of SAMD8."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of VDAC2."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of COMTD1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of FGF23."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of COL4A1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of COL4A2."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of CHRNA5."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of CHRNB4."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of ADAMTS7."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of MORF4L1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of CTSH."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of TOMM40."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of APOE."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of APOC1."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of NECTIN2."Saving 7 x 7 in image
Saving 7 x 7 in image[1] "Projecting the expression of JCAD."Saving 7 x 7 in image
Saving 7 x 7 in image4.3.2 Differential expression between cell communities
Here we project genes to only the broad cell communities:
- macrophages
- endothelial cells
- smooth muscle cells
- T-cells
- B-cells
- Mast cells
- NK-cells
- Mixed cells
4.3.2.1 Macrophages
Comparison between the macrophages cell communities (CD14/CD68+), and all other communities.
N_GENES=20552
MAC.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III"),
ident.2 = c(#"CD14+CD68+ M I",
#"CD14+CD68+ M II",
#"CD14+CD68+ M III",
"CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg",
"CD34+ EC I", "CD34+ EC II",
"Mixed I",
"Mixed II",
"ACTA2+ SMC",
"NCAM1+ NK",
"KIT+ MC",
"CD79A+ B I",
"CD79A+ B II"))
DT::datatable(MAC.markers)MAC_Volcano_TargetsA = EnhancedVolcano(MAC.markers,
lab = rownames(MAC.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "Macrophage markers\n(Macrophage communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
MAC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.MAC.DEG.Targets.pdf"),
plot = MAC_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
MAC.markers <- add_column(MAC.markers, Gene = row.names(MAC.markers), .before = 1)
temp <- MAC.markers[MAC.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".MAC.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)4.3.2.2 Smooth muscle cells
Comparison between the smooth muscle cell communities (ACTA2+), and all other communities.
N_GENES=20552
SMC.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("ACTA2+ SMC"),
ident.2 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III",
"CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg",
"CD34+ EC I", "CD34+ EC II",
"Mixed I",
"Mixed II",
# "ACTA2+ SMC",
"NCAM1+ NK",
"KIT+ MC",
"CD79A+ B I",
"CD79A+ B II"))
| | 0 % ~calculating
|+ | 1 % ~01m 03s
|++ | 2 % ~01m 04s
|++ | 3 % ~59s
|+++ | 4 % ~56s
|+++ | 5 % ~53s
|++++ | 6 % ~01m 09s
|++++ | 7 % ~01m 05s
|+++++ | 9 % ~01m 02s
|+++++ | 10% ~60s
|++++++ | 11% ~58s
|++++++ | 12% ~56s
|+++++++ | 13% ~54s
|+++++++ | 14% ~52s
|++++++++ | 15% ~53s
|++++++++ | 16% ~51s
|+++++++++ | 17% ~50s
|++++++++++ | 18% ~49s
|++++++++++ | 19% ~47s
|+++++++++++ | 20% ~46s
|+++++++++++ | 21% ~45s
|++++++++++++ | 22% ~44s
|++++++++++++ | 23% ~43s
|+++++++++++++ | 24% ~42s
|+++++++++++++ | 26% ~42s
|++++++++++++++ | 27% ~41s
|++++++++++++++ | 28% ~40s
|+++++++++++++++ | 29% ~40s
|+++++++++++++++ | 30% ~39s
|++++++++++++++++ | 31% ~39s
|++++++++++++++++ | 32% ~38s
|+++++++++++++++++ | 33% ~38s
|++++++++++++++++++ | 34% ~37s
|++++++++++++++++++ | 35% ~36s
|+++++++++++++++++++ | 36% ~35s
|+++++++++++++++++++ | 37% ~35s
|++++++++++++++++++++ | 38% ~34s
|++++++++++++++++++++ | 39% ~34s
|+++++++++++++++++++++ | 40% ~34s
|+++++++++++++++++++++ | 41% ~33s
|++++++++++++++++++++++ | 43% ~32s
|++++++++++++++++++++++ | 44% ~32s
|+++++++++++++++++++++++ | 45% ~31s
|+++++++++++++++++++++++ | 46% ~30s
|++++++++++++++++++++++++ | 47% ~30s
|++++++++++++++++++++++++ | 48% ~29s
|+++++++++++++++++++++++++ | 49% ~28s
|+++++++++++++++++++++++++ | 50% ~28s
|++++++++++++++++++++++++++ | 51% ~27s
|+++++++++++++++++++++++++++ | 52% ~26s
|+++++++++++++++++++++++++++ | 53% ~26s
|++++++++++++++++++++++++++++ | 54% ~25s
|++++++++++++++++++++++++++++ | 55% ~24s
|+++++++++++++++++++++++++++++ | 56% ~24s
|+++++++++++++++++++++++++++++ | 57% ~23s
|++++++++++++++++++++++++++++++ | 59% ~23s
|++++++++++++++++++++++++++++++ | 60% ~22s
|+++++++++++++++++++++++++++++++ | 61% ~21s
|+++++++++++++++++++++++++++++++ | 62% ~21s
|++++++++++++++++++++++++++++++++ | 63% ~20s
|++++++++++++++++++++++++++++++++ | 64% ~20s
|+++++++++++++++++++++++++++++++++ | 65% ~19s
|+++++++++++++++++++++++++++++++++ | 66% ~19s
|++++++++++++++++++++++++++++++++++ | 67% ~18s
|+++++++++++++++++++++++++++++++++++ | 68% ~17s
|+++++++++++++++++++++++++++++++++++ | 69% ~17s
|++++++++++++++++++++++++++++++++++++ | 70% ~16s
|++++++++++++++++++++++++++++++++++++ | 71% ~16s
|+++++++++++++++++++++++++++++++++++++ | 72% ~15s
|+++++++++++++++++++++++++++++++++++++ | 73% ~15s
|++++++++++++++++++++++++++++++++++++++ | 74% ~14s
|++++++++++++++++++++++++++++++++++++++ | 76% ~13s
|+++++++++++++++++++++++++++++++++++++++ | 77% ~13s
|+++++++++++++++++++++++++++++++++++++++ | 78% ~12s
|++++++++++++++++++++++++++++++++++++++++ | 79% ~12s
|++++++++++++++++++++++++++++++++++++++++ | 80% ~11s
|+++++++++++++++++++++++++++++++++++++++++ | 81% ~10s
|+++++++++++++++++++++++++++++++++++++++++ | 82% ~10s
|++++++++++++++++++++++++++++++++++++++++++ | 83% ~09s
|+++++++++++++++++++++++++++++++++++++++++++ | 84% ~09s
|+++++++++++++++++++++++++++++++++++++++++++ | 85% ~08s
|++++++++++++++++++++++++++++++++++++++++++++ | 86% ~08s
|++++++++++++++++++++++++++++++++++++++++++++ | 87% ~07s
|+++++++++++++++++++++++++++++++++++++++++++++ | 88% ~06s
|+++++++++++++++++++++++++++++++++++++++++++++ | 89% ~06s
|++++++++++++++++++++++++++++++++++++++++++++++ | 90% ~05s
|++++++++++++++++++++++++++++++++++++++++++++++ | 91% ~05s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 93% ~04s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 94% ~03s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 95% ~03s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 96% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 97% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 98% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 99% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 100% elapsed=53s DT::datatable(SMC.markers)SMC_Volcano_TargetsA = EnhancedVolcano(SMC.markers,
lab = rownames(SMC.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "SMC markers\n(SMC communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
SMC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.SMC.DEG.Targets.pdf"),
plot = SMC_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
SMC.markers <- add_column(SMC.markers, Gene = row.names(SMC.markers), .before = 1)
temp <- SMC.markers[SMC.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".SMC.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)4.3.2.3 Endothelial cells
Comparison between the endothelial cell communities (CD34+), and all other communities.
N_GENES=20552
EC.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("CD34+ EC I", "CD34+ EC II"),
ident.2 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III",
"CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg",
# "CD34+ EC I", "CD34+ EC II",
"Mixed I",
"Mixed II",
"ACTA2+ SMC",
"NCAM1+ NK",
"KIT+ MC",
"CD79A+ B I",
"CD79A+ B II"))
| | 0 % ~calculating
|+ | 1 % ~47s
|++ | 2 % ~46s
|++ | 3 % ~45s
|+++ | 4 % ~44s
|+++ | 5 % ~43s
|++++ | 6 % ~42s
|++++ | 8 % ~41s
|+++++ | 9 % ~40s
|+++++ | 10% ~40s
|++++++ | 11% ~40s
|++++++ | 12% ~39s
|+++++++ | 13% ~41s
|+++++++ | 14% ~40s
|++++++++ | 15% ~39s
|+++++++++ | 16% ~39s
|+++++++++ | 17% ~38s
|++++++++++ | 18% ~37s
|++++++++++ | 19% ~37s
|+++++++++++ | 20% ~36s
|+++++++++++ | 22% ~36s
|++++++++++++ | 23% ~35s
|++++++++++++ | 24% ~34s
|+++++++++++++ | 25% ~34s
|+++++++++++++ | 26% ~33s
|++++++++++++++ | 27% ~33s
|++++++++++++++ | 28% ~33s
|+++++++++++++++ | 29% ~32s
|++++++++++++++++ | 30% ~31s
|++++++++++++++++ | 31% ~31s
|+++++++++++++++++ | 32% ~31s
|+++++++++++++++++ | 33% ~30s
|++++++++++++++++++ | 34% ~30s
|++++++++++++++++++ | 35% ~29s
|+++++++++++++++++++ | 37% ~29s
|+++++++++++++++++++ | 38% ~29s
|++++++++++++++++++++ | 39% ~28s
|++++++++++++++++++++ | 40% ~28s
|+++++++++++++++++++++ | 41% ~27s
|+++++++++++++++++++++ | 42% ~27s
|++++++++++++++++++++++ | 43% ~26s
|+++++++++++++++++++++++ | 44% ~26s
|+++++++++++++++++++++++ | 45% ~25s
|++++++++++++++++++++++++ | 46% ~24s
|++++++++++++++++++++++++ | 47% ~24s
|+++++++++++++++++++++++++ | 48% ~23s
|+++++++++++++++++++++++++ | 49% ~23s
|++++++++++++++++++++++++++ | 51% ~22s
|++++++++++++++++++++++++++ | 52% ~22s
|+++++++++++++++++++++++++++ | 53% ~21s
|+++++++++++++++++++++++++++ | 54% ~21s
|++++++++++++++++++++++++++++ | 55% ~20s
|++++++++++++++++++++++++++++ | 56% ~20s
|+++++++++++++++++++++++++++++ | 57% ~20s
|++++++++++++++++++++++++++++++ | 58% ~20s
|++++++++++++++++++++++++++++++ | 59% ~19s
|+++++++++++++++++++++++++++++++ | 60% ~19s
|+++++++++++++++++++++++++++++++ | 61% ~18s
|++++++++++++++++++++++++++++++++ | 62% ~18s
|++++++++++++++++++++++++++++++++ | 63% ~17s
|+++++++++++++++++++++++++++++++++ | 65% ~17s
|+++++++++++++++++++++++++++++++++ | 66% ~16s
|++++++++++++++++++++++++++++++++++ | 67% ~16s
|++++++++++++++++++++++++++++++++++ | 68% ~16s
|+++++++++++++++++++++++++++++++++++ | 69% ~15s
|+++++++++++++++++++++++++++++++++++ | 70% ~15s
|++++++++++++++++++++++++++++++++++++ | 71% ~14s
|+++++++++++++++++++++++++++++++++++++ | 72% ~14s
|+++++++++++++++++++++++++++++++++++++ | 73% ~13s
|++++++++++++++++++++++++++++++++++++++ | 74% ~13s
|++++++++++++++++++++++++++++++++++++++ | 75% ~12s
|+++++++++++++++++++++++++++++++++++++++ | 76% ~12s
|+++++++++++++++++++++++++++++++++++++++ | 77% ~11s
|++++++++++++++++++++++++++++++++++++++++ | 78% ~11s
|++++++++++++++++++++++++++++++++++++++++ | 80% ~10s
|+++++++++++++++++++++++++++++++++++++++++ | 81% ~10s
|+++++++++++++++++++++++++++++++++++++++++ | 82% ~09s
|++++++++++++++++++++++++++++++++++++++++++ | 83% ~09s
|++++++++++++++++++++++++++++++++++++++++++ | 84% ~08s
|+++++++++++++++++++++++++++++++++++++++++++ | 85% ~07s
|++++++++++++++++++++++++++++++++++++++++++++ | 86% ~07s
|++++++++++++++++++++++++++++++++++++++++++++ | 87% ~06s
|+++++++++++++++++++++++++++++++++++++++++++++ | 88% ~06s
|+++++++++++++++++++++++++++++++++++++++++++++ | 89% ~05s
|++++++++++++++++++++++++++++++++++++++++++++++ | 90% ~05s
|++++++++++++++++++++++++++++++++++++++++++++++ | 91% ~04s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 92% ~04s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 94% ~03s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 95% ~03s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 96% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 97% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 98% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 99% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 100% elapsed=49s DT::datatable(EC.markers)EC_Volcano_TargetsA = EnhancedVolcano(EC.markers,
lab = rownames(EC.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "Endothelial cell markers\n(EC communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
EC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.EC.DEG.Targets.pdf"),
plot = EC_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
EC.markers <- add_column(EC.markers, Gene = row.names(EC.markers), .before = 1)
temp <- EC.markers[EC.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".EC.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)4.3.2.4 T-cells
Comparison between the T-cell communities (CD3/CD4/CD8+), and all other communities.
N_GENES=20552
TC.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg"),
ident.2 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III",
# "CD3+CD8+ T I",
# "CD3+CD8A+ T II ",
# "CD3+CD8 T III",
# "CD3+CD4+ T I",
# "CD3+CD4+ T II",
# "CD3+CD4+ T III",
"CD34+ EC I", "CD34+ EC II",
"Mixed I",
"Mixed II",
"ACTA2+ SMC",
"NCAM1+ NK",
"KIT+ MC",
"CD79A+ B I",
"CD79A+ B II"))
| | 0 % ~calculating
|+ | 1 % ~41s
|++ | 2 % ~37s
|++ | 3 % ~36s
|+++ | 4 % ~36s
|+++ | 5 % ~36s
|++++ | 6 % ~35s
|++++ | 7 % ~34s
|+++++ | 8 % ~34s
|+++++ | 9 % ~33s
|++++++ | 11% ~33s
|++++++ | 12% ~33s
|+++++++ | 13% ~33s
|+++++++ | 14% ~32s
|++++++++ | 15% ~32s
|++++++++ | 16% ~31s
|+++++++++ | 17% ~33s
|+++++++++ | 18% ~32s
|++++++++++ | 19% ~32s
|++++++++++ | 20% ~31s
|+++++++++++ | 21% ~31s
|++++++++++++ | 22% ~30s
|++++++++++++ | 23% ~30s
|+++++++++++++ | 24% ~29s
|+++++++++++++ | 25% ~29s
|++++++++++++++ | 26% ~28s
|++++++++++++++ | 27% ~28s
|+++++++++++++++ | 28% ~27s
|+++++++++++++++ | 29% ~27s
|++++++++++++++++ | 31% ~26s
|++++++++++++++++ | 32% ~26s
|+++++++++++++++++ | 33% ~26s
|+++++++++++++++++ | 34% ~25s
|++++++++++++++++++ | 35% ~25s
|++++++++++++++++++ | 36% ~25s
|+++++++++++++++++++ | 37% ~24s
|+++++++++++++++++++ | 38% ~24s
|++++++++++++++++++++ | 39% ~23s
|++++++++++++++++++++ | 40% ~23s
|+++++++++++++++++++++ | 41% ~22s
|++++++++++++++++++++++ | 42% ~22s
|++++++++++++++++++++++ | 43% ~21s
|+++++++++++++++++++++++ | 44% ~21s
|+++++++++++++++++++++++ | 45% ~21s
|++++++++++++++++++++++++ | 46% ~20s
|++++++++++++++++++++++++ | 47% ~25s
|+++++++++++++++++++++++++ | 48% ~25s
|+++++++++++++++++++++++++ | 49% ~24s
|++++++++++++++++++++++++++ | 51% ~24s
|++++++++++++++++++++++++++ | 52% ~23s
|+++++++++++++++++++++++++++ | 53% ~22s
|+++++++++++++++++++++++++++ | 54% ~22s
|++++++++++++++++++++++++++++ | 55% ~21s
|++++++++++++++++++++++++++++ | 56% ~21s
|+++++++++++++++++++++++++++++ | 57% ~20s
|+++++++++++++++++++++++++++++ | 58% ~19s
|++++++++++++++++++++++++++++++ | 59% ~19s
|++++++++++++++++++++++++++++++ | 60% ~18s
|+++++++++++++++++++++++++++++++ | 61% ~18s
|++++++++++++++++++++++++++++++++ | 62% ~17s
|++++++++++++++++++++++++++++++++ | 63% ~17s
|+++++++++++++++++++++++++++++++++ | 64% ~16s
|+++++++++++++++++++++++++++++++++ | 65% ~16s
|++++++++++++++++++++++++++++++++++ | 66% ~15s
|++++++++++++++++++++++++++++++++++ | 67% ~15s
|+++++++++++++++++++++++++++++++++++ | 68% ~14s
|+++++++++++++++++++++++++++++++++++ | 69% ~14s
|++++++++++++++++++++++++++++++++++++ | 71% ~13s
|++++++++++++++++++++++++++++++++++++ | 72% ~13s
|+++++++++++++++++++++++++++++++++++++ | 73% ~12s
|+++++++++++++++++++++++++++++++++++++ | 74% ~12s
|++++++++++++++++++++++++++++++++++++++ | 75% ~11s
|++++++++++++++++++++++++++++++++++++++ | 76% ~11s
|+++++++++++++++++++++++++++++++++++++++ | 77% ~10s
|+++++++++++++++++++++++++++++++++++++++ | 78% ~10s
|++++++++++++++++++++++++++++++++++++++++ | 79% ~09s
|++++++++++++++++++++++++++++++++++++++++ | 80% ~09s
|+++++++++++++++++++++++++++++++++++++++++ | 81% ~08s
|++++++++++++++++++++++++++++++++++++++++++ | 82% ~08s
|++++++++++++++++++++++++++++++++++++++++++ | 83% ~07s
|+++++++++++++++++++++++++++++++++++++++++++ | 84% ~07s
|+++++++++++++++++++++++++++++++++++++++++++ | 85% ~07s
|++++++++++++++++++++++++++++++++++++++++++++ | 86% ~06s
|++++++++++++++++++++++++++++++++++++++++++++ | 87% ~06s
|+++++++++++++++++++++++++++++++++++++++++++++ | 88% ~05s
|+++++++++++++++++++++++++++++++++++++++++++++ | 89% ~05s
|++++++++++++++++++++++++++++++++++++++++++++++ | 91% ~04s
|++++++++++++++++++++++++++++++++++++++++++++++ | 92% ~04s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 93% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 94% ~03s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 95% ~02s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 96% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 97% ~01s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 98% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 99% ~00s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 100% elapsed=43s DT::datatable(TC.markers)TC_Volcano_TargetsA = EnhancedVolcano(TC.markers,
lab = rownames(TC.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "T-cell markers\n(T-cell communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
TC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.TC.DEG.Targets.pdf"),
plot = TC_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
TC.markers <- add_column(TC.markers, Gene = row.names(TC.markers), .before = 1)
temp <- TC.markers[TC.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".TC.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)4.3.2.5 B-cells
Comparison between the B-cell communities (CD79A+), and all other communities.
N_GENES=20552
BC.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("CD79A+ B I",
"CD79A+ B II"),
ident.2 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III",
"CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg",
"CD34+ EC I", "CD34+ EC II",
"Mixed I",
"Mixed II",
"ACTA2+ SMC",
"NCAM1+ NK",
"KIT+ MC"))
| | 0 % ~calculating
|+ | 1 % ~26s
|++ | 2 % ~26s
|++ | 3 % ~25s
|+++ | 4 % ~25s
|+++ | 5 % ~24s
|++++ | 6 % ~24s
|++++ | 7 % ~24s
|+++++ | 8 % ~23s
|+++++ | 9 % ~23s
|++++++ | 10% ~23s
|++++++ | 11% ~23s
|+++++++ | 12% ~24s
|+++++++ | 13% ~24s
|++++++++ | 14% ~23s
|++++++++ | 15% ~23s
|+++++++++ | 16% ~23s
|+++++++++ | 17% ~22s
|++++++++++ | 18% ~22s
|++++++++++ | 19% ~21s
|+++++++++++ | 20% ~21s
|+++++++++++ | 21% ~21s
|++++++++++++ | 22% ~20s
|++++++++++++ | 23% ~20s
|+++++++++++++ | 24% ~20s
|+++++++++++++ | 26% ~19s
|++++++++++++++ | 27% ~19s
|++++++++++++++ | 28% ~19s
|+++++++++++++++ | 29% ~19s
|+++++++++++++++ | 30% ~18s
|++++++++++++++++ | 31% ~18s
|++++++++++++++++ | 32% ~18s
|+++++++++++++++++ | 33% ~18s
|+++++++++++++++++ | 34% ~18s
|++++++++++++++++++ | 35% ~17s
|++++++++++++++++++ | 36% ~17s
|+++++++++++++++++++ | 37% ~17s
|+++++++++++++++++++ | 38% ~17s
|++++++++++++++++++++ | 39% ~16s
|++++++++++++++++++++ | 40% ~16s
|+++++++++++++++++++++ | 41% ~16s
|+++++++++++++++++++++ | 42% ~16s
|++++++++++++++++++++++ | 43% ~15s
|++++++++++++++++++++++ | 44% ~15s
|+++++++++++++++++++++++ | 45% ~15s
|+++++++++++++++++++++++ | 46% ~15s
|++++++++++++++++++++++++ | 47% ~14s
|++++++++++++++++++++++++ | 48% ~14s
|+++++++++++++++++++++++++ | 49% ~14s
|+++++++++++++++++++++++++ | 50% ~14s
|++++++++++++++++++++++++++ | 51% ~14s
|+++++++++++++++++++++++++++ | 52% ~13s
|+++++++++++++++++++++++++++ | 53% ~13s
|++++++++++++++++++++++++++++ | 54% ~13s
|++++++++++++++++++++++++++++ | 55% ~12s
|+++++++++++++++++++++++++++++ | 56% ~12s
|+++++++++++++++++++++++++++++ | 57% ~12s
|++++++++++++++++++++++++++++++ | 58% ~11s
|++++++++++++++++++++++++++++++ | 59% ~11s
|+++++++++++++++++++++++++++++++ | 60% ~11s
|+++++++++++++++++++++++++++++++ | 61% ~10s
|++++++++++++++++++++++++++++++++ | 62% ~10s
|++++++++++++++++++++++++++++++++ | 63% ~10s
|+++++++++++++++++++++++++++++++++ | 64% ~10s
|+++++++++++++++++++++++++++++++++ | 65% ~09s
|++++++++++++++++++++++++++++++++++ | 66% ~09s
|++++++++++++++++++++++++++++++++++ | 67% ~09s
|+++++++++++++++++++++++++++++++++++ | 68% ~08s
|+++++++++++++++++++++++++++++++++++ | 69% ~08s
|++++++++++++++++++++++++++++++++++++ | 70% ~08s
|++++++++++++++++++++++++++++++++++++ | 71% ~08s
|+++++++++++++++++++++++++++++++++++++ | 72% ~07s
|+++++++++++++++++++++++++++++++++++++ | 73% ~07s
|++++++++++++++++++++++++++++++++++++++ | 74% ~07s
|++++++++++++++++++++++++++++++++++++++ | 76% ~07s
|+++++++++++++++++++++++++++++++++++++++ | 77% ~06s
|+++++++++++++++++++++++++++++++++++++++ | 78% ~06s
|++++++++++++++++++++++++++++++++++++++++ | 79% ~06s
|++++++++++++++++++++++++++++++++++++++++ | 80% ~06s
|+++++++++++++++++++++++++++++++++++++++++ | 81% ~05s
|+++++++++++++++++++++++++++++++++++++++++ | 82% ~05s
|++++++++++++++++++++++++++++++++++++++++++ | 83% ~05s
|++++++++++++++++++++++++++++++++++++++++++ | 84% ~05s
|+++++++++++++++++++++++++++++++++++++++++++ | 85% ~04s
|+++++++++++++++++++++++++++++++++++++++++++ | 86% ~04s
|++++++++++++++++++++++++++++++++++++++++++++ | 87% ~04s
|++++++++++++++++++++++++++++++++++++++++++++ | 88% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++ | 89% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++ | 90% ~03s
|++++++++++++++++++++++++++++++++++++++++++++++ | 91% ~03s
|++++++++++++++++++++++++++++++++++++++++++++++ | 92% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 93% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 94% ~02s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 95% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 96% ~01s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 97% ~01s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 98% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 99% ~00s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 100% elapsed=27s DT::datatable(BC.markers)BC_Volcano_TargetsA = EnhancedVolcano(BC.markers,
lab = rownames(BC.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "B-cell markers\n(B-cell communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
BC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.BC.DEG.Targets.pdf"),
plot = BC_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
BC.markers <- add_column(BC.markers, Gene = row.names(BC.markers), .before = 1)
temp <- BC.markers[BC.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".BC.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)4.3.2.6 Mast cells
Comparison between the mast cell communities (KIT+), and all other communities.
N_GENES=20552
MC.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("KIT+ MC"),
ident.2 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III",
"CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg",
"CD34+ EC I", "CD34+ EC II",
"Mixed I",
"Mixed II",
"ACTA2+ SMC",
"NCAM1+ NK",
# "KIT+ MC",
"CD79A+ B I",
"CD79A+ B II"))
| | 0 % ~calculating
|+ | 1 % ~43s
|++ | 2 % ~41s
|++ | 3 % ~39s
|+++ | 4 % ~37s
|+++ | 5 % ~36s
|++++ | 6 % ~35s
|++++ | 7 % ~34s
|+++++ | 8 % ~34s
|+++++ | 9 % ~33s
|++++++ | 10% ~32s
|++++++ | 11% ~32s
|+++++++ | 12% ~32s
|+++++++ | 13% ~32s
|++++++++ | 14% ~31s
|++++++++ | 15% ~31s
|+++++++++ | 16% ~31s
|+++++++++ | 17% ~45s
|++++++++++ | 18% ~44s
|++++++++++ | 19% ~43s
|+++++++++++ | 20% ~41s
|+++++++++++ | 21% ~40s
|++++++++++++ | 22% ~39s
|++++++++++++ | 23% ~38s
|+++++++++++++ | 24% ~37s
|+++++++++++++ | 25% ~36s
|++++++++++++++ | 26% ~35s
|++++++++++++++ | 27% ~35s
|+++++++++++++++ | 28% ~34s
|+++++++++++++++ | 29% ~33s
|++++++++++++++++ | 30% ~32s
|++++++++++++++++ | 31% ~31s
|+++++++++++++++++ | 32% ~31s
|+++++++++++++++++ | 33% ~30s
|++++++++++++++++++ | 34% ~29s
|++++++++++++++++++ | 35% ~29s
|+++++++++++++++++++ | 36% ~28s
|+++++++++++++++++++ | 37% ~28s
|++++++++++++++++++++ | 38% ~27s
|++++++++++++++++++++ | 39% ~27s
|+++++++++++++++++++++ | 40% ~26s
|+++++++++++++++++++++ | 41% ~26s
|++++++++++++++++++++++ | 42% ~25s
|++++++++++++++++++++++ | 43% ~25s
|+++++++++++++++++++++++ | 44% ~24s
|+++++++++++++++++++++++ | 45% ~23s
|++++++++++++++++++++++++ | 46% ~23s
|++++++++++++++++++++++++ | 47% ~22s
|+++++++++++++++++++++++++ | 48% ~22s
|+++++++++++++++++++++++++ | 49% ~21s
|++++++++++++++++++++++++++ | 51% ~21s
|++++++++++++++++++++++++++ | 52% ~21s
|+++++++++++++++++++++++++++ | 53% ~20s
|+++++++++++++++++++++++++++ | 54% ~20s
|++++++++++++++++++++++++++++ | 55% ~19s
|++++++++++++++++++++++++++++ | 56% ~19s
|+++++++++++++++++++++++++++++ | 57% ~18s
|+++++++++++++++++++++++++++++ | 58% ~18s
|++++++++++++++++++++++++++++++ | 59% ~17s
|++++++++++++++++++++++++++++++ | 60% ~17s
|+++++++++++++++++++++++++++++++ | 61% ~16s
|+++++++++++++++++++++++++++++++ | 62% ~16s
|++++++++++++++++++++++++++++++++ | 63% ~16s
|++++++++++++++++++++++++++++++++ | 64% ~15s
|+++++++++++++++++++++++++++++++++ | 65% ~15s
|+++++++++++++++++++++++++++++++++ | 66% ~14s
|++++++++++++++++++++++++++++++++++ | 67% ~14s
|++++++++++++++++++++++++++++++++++ | 68% ~13s
|+++++++++++++++++++++++++++++++++++ | 69% ~13s
|+++++++++++++++++++++++++++++++++++ | 70% ~13s
|++++++++++++++++++++++++++++++++++++ | 71% ~12s
|++++++++++++++++++++++++++++++++++++ | 72% ~12s
|+++++++++++++++++++++++++++++++++++++ | 73% ~11s
|+++++++++++++++++++++++++++++++++++++ | 74% ~11s
|++++++++++++++++++++++++++++++++++++++ | 75% ~10s
|++++++++++++++++++++++++++++++++++++++ | 76% ~10s
|+++++++++++++++++++++++++++++++++++++++ | 77% ~10s
|+++++++++++++++++++++++++++++++++++++++ | 78% ~09s
|++++++++++++++++++++++++++++++++++++++++ | 79% ~09s
|++++++++++++++++++++++++++++++++++++++++ | 80% ~08s
|+++++++++++++++++++++++++++++++++++++++++ | 81% ~08s
|+++++++++++++++++++++++++++++++++++++++++ | 82% ~07s
|++++++++++++++++++++++++++++++++++++++++++ | 83% ~07s
|++++++++++++++++++++++++++++++++++++++++++ | 84% ~07s
|+++++++++++++++++++++++++++++++++++++++++++ | 85% ~06s
|+++++++++++++++++++++++++++++++++++++++++++ | 86% ~06s
|++++++++++++++++++++++++++++++++++++++++++++ | 87% ~05s
|++++++++++++++++++++++++++++++++++++++++++++ | 88% ~05s
|+++++++++++++++++++++++++++++++++++++++++++++ | 89% ~05s
|+++++++++++++++++++++++++++++++++++++++++++++ | 90% ~04s
|++++++++++++++++++++++++++++++++++++++++++++++ | 91% ~04s
|++++++++++++++++++++++++++++++++++++++++++++++ | 92% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 93% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 94% ~02s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 95% ~02s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 96% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 97% ~01s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 98% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 99% ~00s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 100% elapsed=40s DT::datatable(MC.markers)MC_Volcano_TargetsA = EnhancedVolcano(MC.markers,
lab = rownames(MC.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "Mast cell markers\n(Mast cell communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
MC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.MC.DEG.Targets.pdf"),
plot = MC_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
MC.markers <- add_column(MC.markers, Gene = row.names(MC.markers), .before = 1)
temp <- MC.markers[MC.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".MC.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)4.3.2.7 NK-cells
Comparison between the natural killer cell communities (NCAM1+), and all other communities.
N_GENES=20552
NK.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("NCAM1+ NK"),
ident.2 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III",
"CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg",
"CD34+ EC I", "CD34+ EC II",
"Mixed I",
"Mixed II",
#"NCAM1+ NK",
"ACTA2+ SMC",
"KIT+ MC",
"CD79A+ B I",
"CD79A+ B II"))
| | 0 % ~calculating
|+ | 1 % ~20s
|++ | 2 % ~19s
|++ | 3 % ~19s
|+++ | 4 % ~22s
|+++ | 5 % ~22s
|++++ | 6 % ~21s
|++++ | 7 % ~21s
|+++++ | 8 % ~23s
|+++++ | 9 % ~22s
|++++++ | 10% ~22s
|++++++ | 11% ~21s
|+++++++ | 12% ~20s
|+++++++ | 13% ~20s
|++++++++ | 14% ~19s
|++++++++ | 15% ~19s
|+++++++++ | 16% ~19s
|+++++++++ | 17% ~18s
|++++++++++ | 18% ~18s
|++++++++++ | 19% ~18s
|+++++++++++ | 20% ~17s
|+++++++++++ | 21% ~17s
|++++++++++++ | 22% ~17s
|++++++++++++ | 23% ~16s
|+++++++++++++ | 24% ~16s
|+++++++++++++ | 25% ~16s
|++++++++++++++ | 26% ~16s
|++++++++++++++ | 27% ~15s
|+++++++++++++++ | 28% ~15s
|+++++++++++++++ | 29% ~15s
|++++++++++++++++ | 30% ~15s
|++++++++++++++++ | 31% ~14s
|+++++++++++++++++ | 32% ~14s
|+++++++++++++++++ | 33% ~14s
|++++++++++++++++++ | 34% ~14s
|++++++++++++++++++ | 35% ~13s
|+++++++++++++++++++ | 36% ~13s
|+++++++++++++++++++ | 37% ~13s
|++++++++++++++++++++ | 38% ~13s
|++++++++++++++++++++ | 39% ~13s
|+++++++++++++++++++++ | 40% ~12s
|+++++++++++++++++++++ | 41% ~12s
|++++++++++++++++++++++ | 42% ~12s
|++++++++++++++++++++++ | 43% ~12s
|+++++++++++++++++++++++ | 44% ~11s
|+++++++++++++++++++++++ | 45% ~11s
|++++++++++++++++++++++++ | 46% ~11s
|++++++++++++++++++++++++ | 47% ~11s
|+++++++++++++++++++++++++ | 48% ~11s
|+++++++++++++++++++++++++ | 49% ~11s
|++++++++++++++++++++++++++ | 51% ~11s
|++++++++++++++++++++++++++ | 52% ~10s
|+++++++++++++++++++++++++++ | 53% ~10s
|+++++++++++++++++++++++++++ | 54% ~10s
|++++++++++++++++++++++++++++ | 55% ~10s
|++++++++++++++++++++++++++++ | 56% ~09s
|+++++++++++++++++++++++++++++ | 57% ~09s
|+++++++++++++++++++++++++++++ | 58% ~09s
|++++++++++++++++++++++++++++++ | 59% ~09s
|++++++++++++++++++++++++++++++ | 60% ~09s
|+++++++++++++++++++++++++++++++ | 61% ~08s
|+++++++++++++++++++++++++++++++ | 62% ~08s
|++++++++++++++++++++++++++++++++ | 63% ~08s
|++++++++++++++++++++++++++++++++ | 64% ~08s
|+++++++++++++++++++++++++++++++++ | 65% ~08s
|+++++++++++++++++++++++++++++++++ | 66% ~07s
|++++++++++++++++++++++++++++++++++ | 67% ~07s
|++++++++++++++++++++++++++++++++++ | 68% ~07s
|+++++++++++++++++++++++++++++++++++ | 69% ~07s
|+++++++++++++++++++++++++++++++++++ | 70% ~06s
|++++++++++++++++++++++++++++++++++++ | 71% ~06s
|++++++++++++++++++++++++++++++++++++ | 72% ~06s
|+++++++++++++++++++++++++++++++++++++ | 73% ~06s
|+++++++++++++++++++++++++++++++++++++ | 74% ~06s
|++++++++++++++++++++++++++++++++++++++ | 75% ~05s
|++++++++++++++++++++++++++++++++++++++ | 76% ~05s
|+++++++++++++++++++++++++++++++++++++++ | 77% ~05s
|+++++++++++++++++++++++++++++++++++++++ | 78% ~05s
|++++++++++++++++++++++++++++++++++++++++ | 79% ~05s
|++++++++++++++++++++++++++++++++++++++++ | 80% ~04s
|+++++++++++++++++++++++++++++++++++++++++ | 81% ~04s
|+++++++++++++++++++++++++++++++++++++++++ | 82% ~04s
|++++++++++++++++++++++++++++++++++++++++++ | 83% ~04s
|++++++++++++++++++++++++++++++++++++++++++ | 84% ~04s
|+++++++++++++++++++++++++++++++++++++++++++ | 85% ~03s
|+++++++++++++++++++++++++++++++++++++++++++ | 86% ~03s
|++++++++++++++++++++++++++++++++++++++++++++ | 87% ~03s
|++++++++++++++++++++++++++++++++++++++++++++ | 88% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++ | 89% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++ | 90% ~02s
|++++++++++++++++++++++++++++++++++++++++++++++ | 91% ~02s
|++++++++++++++++++++++++++++++++++++++++++++++ | 92% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 93% ~02s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 94% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 95% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 96% ~01s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 97% ~01s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 98% ~00s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 99% ~00s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 100% elapsed=22s DT::datatable(NK.markers)NK_Volcano_TargetsA = EnhancedVolcano(NK.markers,
lab = rownames(NK.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "NK markers\n(NK-cell communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
NK_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.NK.DEG.Targets.pdf"),
plot = NK_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
NK.markers <- add_column(NK.markers, Gene = row.names(NK.markers), .before = 1)
temp <- NK.markers[NK.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".NK.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)4.3.2.8 Mixed cells
Comparison between the mixed cell communities, and all other communities.
N_GENES=20552
MIXED.markers <- FindMarkers(object = scRNAseqData,
ident.1 = c("Mixed I",
"Mixed II"),
ident.2 = c("CD14+CD68+ M I",
"CD14+CD68+ M II",
"CD14+CD68+ M III",
"CD3+CD8A+ T I",
"CD3+CD8A+ T II ",
"CD3+CD8A+ T III",
"CD3+CD4+ T I",
"CD3+CD4+ T II",
"CD3+ Treg",
"CD34+ EC I", "CD34+ EC II",
# "Mixed I",
# "Mixed II",
"ACTA2+ SMC",
"NCAM1+ NK",
"KIT+ MC",
"CD79A+ B I",
"CD79A+ B II"))
| | 0 % ~calculating
|+ | 1 % ~01m 18s
|++ | 2 % ~01m 16s
|++ | 3 % ~01m 14s
|+++ | 4 % ~01m 11s
|+++ | 5 % ~01m 10s
|++++ | 6 % ~01m 09s
|++++ | 7 % ~01m 08s
|+++++ | 8 % ~01m 07s
|+++++ | 9 % ~01m 06s
|++++++ | 10% ~01m 05s
|++++++ | 11% ~01m 08s
|+++++++ | 12% ~01m 07s
|+++++++ | 13% ~01m 06s
|++++++++ | 14% ~01m 05s
|++++++++ | 15% ~01m 04s
|+++++++++ | 16% ~01m 03s
|+++++++++ | 17% ~01m 01s
|++++++++++ | 18% ~60s
|++++++++++ | 19% ~59s
|+++++++++++ | 20% ~01m 17s
|+++++++++++ | 21% ~01m 15s
|++++++++++++ | 22% ~01m 13s
|++++++++++++ | 23% ~01m 11s
|+++++++++++++ | 24% ~01m 09s
|+++++++++++++ | 26% ~01m 07s
|++++++++++++++ | 27% ~01m 06s
|++++++++++++++ | 28% ~01m 04s
|+++++++++++++++ | 29% ~01m 02s
|+++++++++++++++ | 30% ~01m 02s
|++++++++++++++++ | 31% ~01m 01s
|++++++++++++++++ | 32% ~01m 00s
|+++++++++++++++++ | 33% ~59s
|+++++++++++++++++ | 34% ~58s
|++++++++++++++++++ | 35% ~58s
|++++++++++++++++++ | 36% ~56s
|+++++++++++++++++++ | 37% ~55s
|+++++++++++++++++++ | 38% ~54s
|++++++++++++++++++++ | 39% ~53s
|++++++++++++++++++++ | 40% ~52s
|+++++++++++++++++++++ | 41% ~51s
|+++++++++++++++++++++ | 42% ~50s
|++++++++++++++++++++++ | 43% ~50s
|++++++++++++++++++++++ | 44% ~49s
|+++++++++++++++++++++++ | 45% ~48s
|+++++++++++++++++++++++ | 46% ~47s
|++++++++++++++++++++++++ | 47% ~46s
|++++++++++++++++++++++++ | 48% ~45s
|+++++++++++++++++++++++++ | 49% ~44s
|+++++++++++++++++++++++++ | 50% ~43s
|++++++++++++++++++++++++++ | 51% ~43s
|+++++++++++++++++++++++++++ | 52% ~42s
|+++++++++++++++++++++++++++ | 53% ~41s
|++++++++++++++++++++++++++++ | 54% ~40s
|++++++++++++++++++++++++++++ | 55% ~39s
|+++++++++++++++++++++++++++++ | 56% ~38s
|+++++++++++++++++++++++++++++ | 57% ~37s
|++++++++++++++++++++++++++++++ | 58% ~37s
|++++++++++++++++++++++++++++++ | 59% ~36s
|+++++++++++++++++++++++++++++++ | 60% ~35s
|+++++++++++++++++++++++++++++++ | 61% ~34s
|++++++++++++++++++++++++++++++++ | 62% ~33s
|++++++++++++++++++++++++++++++++ | 63% ~32s
|+++++++++++++++++++++++++++++++++ | 64% ~31s
|+++++++++++++++++++++++++++++++++ | 65% ~31s
|++++++++++++++++++++++++++++++++++ | 66% ~30s
|++++++++++++++++++++++++++++++++++ | 67% ~29s
|+++++++++++++++++++++++++++++++++++ | 68% ~28s
|+++++++++++++++++++++++++++++++++++ | 69% ~27s
|++++++++++++++++++++++++++++++++++++ | 70% ~26s
|++++++++++++++++++++++++++++++++++++ | 71% ~25s
|+++++++++++++++++++++++++++++++++++++ | 72% ~24s
|+++++++++++++++++++++++++++++++++++++ | 73% ~23s
|++++++++++++++++++++++++++++++++++++++ | 74% ~22s
|++++++++++++++++++++++++++++++++++++++ | 76% ~21s
|+++++++++++++++++++++++++++++++++++++++ | 77% ~20s
|+++++++++++++++++++++++++++++++++++++++ | 78% ~19s
|++++++++++++++++++++++++++++++++++++++++ | 79% ~19s
|++++++++++++++++++++++++++++++++++++++++ | 80% ~18s
|+++++++++++++++++++++++++++++++++++++++++ | 81% ~17s
|+++++++++++++++++++++++++++++++++++++++++ | 82% ~16s
|++++++++++++++++++++++++++++++++++++++++++ | 83% ~15s
|++++++++++++++++++++++++++++++++++++++++++ | 84% ~14s
|+++++++++++++++++++++++++++++++++++++++++++ | 85% ~13s
|+++++++++++++++++++++++++++++++++++++++++++ | 86% ~12s
|++++++++++++++++++++++++++++++++++++++++++++ | 87% ~11s
|++++++++++++++++++++++++++++++++++++++++++++ | 88% ~10s
|+++++++++++++++++++++++++++++++++++++++++++++ | 89% ~09s
|+++++++++++++++++++++++++++++++++++++++++++++ | 90% ~09s
|++++++++++++++++++++++++++++++++++++++++++++++ | 91% ~08s
|++++++++++++++++++++++++++++++++++++++++++++++ | 92% ~07s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 93% ~06s
|+++++++++++++++++++++++++++++++++++++++++++++++ | 94% ~05s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 95% ~04s
|++++++++++++++++++++++++++++++++++++++++++++++++ | 96% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 97% ~03s
|+++++++++++++++++++++++++++++++++++++++++++++++++ | 98% ~02s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 99% ~01s
|++++++++++++++++++++++++++++++++++++++++++++++++++| 100% elapsed=01m 23sDT::datatable(MIXED.markers)MIXED_Volcano_TargetsA = EnhancedVolcano(MIXED.markers,
lab = rownames(MIXED.markers),
x = "avg_log2FC",
y = "p_val_adj",
selectLab = target_genes_qc,
axisLabSize = 12,
xlab = "average fold-change",
title = "Mixed markers\n(Mixed cell communities vs the rest)",
titleLabSize = 14,
pCutoff = 0.05/N_GENES, # 20552 genes
FCcutoff = 1.25,
pointSize = 1.5,
labSize = 3.0,
legendLabels =c('NS','avg. fold-change','P',
'P & avg. fold-change'),
legendPosition = "right",
legendLabSize = 10,
legendIconSize = 3.0,
drawConnectors = TRUE,
widthConnectors = 0.2,
colConnectors = "#595A5C",
gridlines.major = FALSE,
gridlines.minor = FALSE)
MIXED_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.MIXED.DEG.Targets.pdf"),
plot = MIXED_Volcano_TargetsA)Saving 7.29 x 4.51 in image
The target results are given below and written to a file.
library(tibble)
MIXED.markers <- add_column(MIXED.markers, Gene = row.names(MIXED.markers), .before = 1)
temp <- MIXED.markers[MIXED.markers$Gene %in% target_genes_qc,]
DT::datatable(temp)fwrite(temp, file = paste0(OUT_loc, "/", Today, ".MIXED.DEG.Targets.txt"),
quote = FALSE,
sep = "\t",
showProgress = FALSE, verbose = FALSE)5 Top hits
Dotplots of known and novel genes.
Some genes were not found in our data.
- DMRTA1 (known)
- LINC00841 (novel)
- LOC100130539 (novel)
library(RColorBrewer)
# "C6orf195" "EDN1" "PHACTR1" "TBC1D7" "GFOD1" "ENPP1" "ENPP3" "IGFBP3"
# "AC011294.3" "MTAP" "RP11-145E5.5" "C9orf53" "CDKN2A" "CDKN2B" "ZNF485" "ZNF32"
# "AL137026.1" "ARID5B" "RTKN2" "CAMK2G" "VCL" "AP3M1" "ADK" "KAT6B"
# "DUPD1" "DUSP13" "SAMD8" "VDAC2" "COMTD1" "FGF23" "COL4A1" "COL4A2"
# "CHRNA5" "CHRNB4" "ADAMTS7" "MORF4L1" "CTSH" "BCAM" "PVRL2" "TOMM40"
# "APOE" "APOC1"
tophits_known <- c("PHACTR1", "CDKN2B-AS1","APOE") # DMRTA1 not found in the data
tophits_novel <- c("ENPP3", "ENPP1", "IGFBP3","ARID5B","ADK", "FGF23", "COL4A2", "ADAMTS7", "MORF4L1") # "LINC00841", "LOC100130539" not found in the data
p1 <- DotPlot(scRNAseqData, features = tophits_known,
cols = "RdBu")
p1 + theme(axis.text.x = element_text(angle = 45, hjust=1, size = 5))
ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.known.png"), plot = last_plot())Saving 7.29 x 4.51 in imageggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.known.ps"), plot = last_plot())Saving 7.29 x 4.51 in image
rm(p1)
p1 <- DotPlot(scRNAseqData, features = tophits_novel,
cols = "RdBu")
p1 + theme(axis.text.x = element_text(angle = 45, hjust=1, size = 5))
ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.novel.png"), plot = last_plot())Saving 7.29 x 4.51 in imageggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.novel.ps"), plot = last_plot())Saving 7.29 x 4.51 in image
rm(p1)
6 Session information
Version: v1.0.2
Last update: 2021-07-15
Written by: Sander W. van der Laan (s.w.vanderlaan-2[at]umcutrecht.nl).
Description: Script to load single-cell RNA sequencing (scRNAseq) data, and perform quality control (QC), and initial mapping to cells.
Minimum requirements: R version 3.5.2 (2018-12-20) -- 'Eggshell Igloo', macOS Mojave (10.14.2).
Change log
* v1.0.2 Update to the gene list, workflow, and dataset.
* v1.0.1 Update to the gene list.
* v1.0.0 Initial versionsessionInfo()R version 4.1.0 (2021-05-18)
Platform: x86_64-apple-darwin17.0 (64-bit)
Running under: macOS Big Sur 11.4
Matrix products: default
LAPACK: /Library/Frameworks/R.framework/Versions/4.1/Resources/lib/libRlapack.dylib
locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
attached base packages:
[1] parallel stats4 tools stats graphics grDevices utils datasets methods base
other attached packages:
[1] RColorBrewer_1.1-2 labelled_2.8.0 openxlsx_4.2.4 SeuratObject_4.0.2 Seurat_4.0.1
[6] devtools_2.4.2 usethis_2.0.1 tableone_0.13.0 haven_2.4.1 EnhancedVolcano_1.10.0
[11] ggrepel_0.9.1 mygene_1.28.0 GenomicFeatures_1.44.0 GenomicRanges_1.44.0 GenomeInfoDb_1.28.1
[16] org.Hs.eg.db_3.13.0 AnnotationDbi_1.54.1 IRanges_2.26.0 S4Vectors_0.30.0 Biobase_2.52.0
[21] BiocGenerics_0.38.0 DT_0.18 knitr_1.33 forcats_0.5.1 stringr_1.4.0
[26] purrr_0.3.4 tibble_3.1.2 ggplot2_3.3.5 tidyverse_1.3.1 data.table_1.14.0
[31] naniar_0.6.1 tidylog_1.0.2 tidyr_1.1.3 dplyr_1.0.7 optparse_1.6.6
[36] readr_1.4.0
loaded via a namespace (and not attached):
[1] rappdirs_0.3.3 rtracklayer_1.52.0 scattermore_0.7 ragg_1.1.3
[5] visdat_0.5.3 bit64_4.0.5 irlba_2.3.3 DelayedArray_0.18.0
[9] rpart_4.1-15 KEGGREST_1.32.0 RCurl_1.98-1.3 generics_0.1.0
[13] callr_3.7.0 cowplot_1.1.1 RSQLite_2.2.7 RANN_2.6.1
[17] proxy_0.4-26 future_1.21.0 chron_2.3-56 bit_4.0.4
[21] spatstat.data_2.1-0 xml2_1.3.2 lubridate_1.7.10 httpuv_1.6.1
[25] SummarizedExperiment_1.22.0 assertthat_0.2.1 xfun_0.24 jquerylib_0.1.4
[29] hms_1.1.0 evaluate_0.14 promises_1.2.0.1 fansi_0.5.0
[33] restfulr_0.0.13 progress_1.2.2 dbplyr_2.1.1 readxl_1.3.1
[37] igraph_1.2.6 DBI_1.1.1 htmlwidgets_1.5.3 spatstat.geom_2.2-2
[41] ellipsis_0.3.2 crosstalk_1.1.1 backports_1.2.1 survey_4.0
[45] biomaRt_2.48.2 deldir_0.2-10 MatrixGenerics_1.4.0 vctrs_0.3.8
[49] remotes_2.4.0 ROCR_1.0-11 abind_1.4-5 cachem_1.0.5
[53] withr_2.4.2 checkmate_2.0.0 sctransform_0.3.2 GenomicAlignments_1.28.0
[57] prettyunits_1.1.1 getopt_1.20.3 goftest_1.2-2 cluster_2.1.2
[61] lazyeval_0.2.2 crayon_1.4.1 labeling_0.4.2 pkgconfig_2.0.3
[65] pkgload_1.2.1 nlme_3.1-152 vipor_0.4.5 nnet_7.3-16
[69] rlang_0.4.11 globals_0.14.0 lifecycle_1.0.0 miniUI_0.1.1.1
[73] filelock_1.0.2 extrafontdb_1.0 BiocFileCache_2.0.0 modelr_0.1.8
[77] rprojroot_2.0.2 ggrastr_0.2.3 cellranger_1.1.0 polyclip_1.10-0
[81] matrixStats_0.59.0 lmtest_0.9-38 Matrix_1.3-4 zoo_1.8-9
[85] reprex_2.0.0 base64enc_0.1-3 beeswarm_0.4.0 processx_3.5.2
[89] ggridges_0.5.3 png_0.1-7 viridisLite_0.4.0 rjson_0.2.20
[93] clisymbols_1.2.0 bitops_1.0-7 KernSmooth_2.23-20 Biostrings_2.60.1
[97] blob_1.2.1 parallelly_1.26.1 jpeg_0.1-8.1 scales_1.1.1
[101] memoise_2.0.0 magrittr_2.0.1 plyr_1.8.6 ica_1.0-2
[105] zlibbioc_1.38.0 compiler_4.1.0 BiocIO_1.2.0 ash_1.0-15
[109] fitdistrplus_1.1-5 Rsamtools_2.8.0 cli_3.0.0 XVector_0.32.0
[113] listenv_0.8.0 ps_1.6.0 patchwork_1.1.1 pbapply_1.4-3
[117] htmlTable_2.2.1 Formula_1.2-4 MASS_7.3-54 mgcv_1.8-36
[121] tidyselect_1.1.1 stringi_1.7.2 textshaping_0.3.5 proj4_1.0-10.1
[125] mitools_2.4 yaml_2.2.1 latticeExtra_0.6-29 grid_4.1.0
[129] sass_0.4.0 future.apply_1.7.0 rstudioapi_0.13 foreign_0.8-81
[133] gridExtra_2.3 farver_2.1.0 Rtsne_0.15 digest_0.6.27
[137] shiny_1.6.0 proto_1.0.0 Rcpp_1.0.7 broom_0.7.8
[141] ggalt_0.4.0 later_1.2.0 RcppAnnoy_0.0.18 httr_1.4.2
[145] colorspace_2.0-2 rvest_1.0.0 XML_3.99-0.6 fs_1.5.0
[149] tensor_1.5 reticulate_1.20 splines_4.1.0 uwot_0.1.10
[153] spatstat.utils_2.2-0 systemfonts_1.0.2 sessioninfo_1.1.1 plotly_4.9.4.1
[157] xtable_1.8-4 jsonlite_1.7.2 testthat_3.0.4 R6_2.5.0
[161] Hmisc_4.5-0 gsubfn_0.7 pillar_1.6.1 htmltools_0.5.1.1
[165] mime_0.11 glue_1.4.2 fastmap_1.1.0 BiocParallel_1.26.1
[169] class_7.3-19 codetools_0.2-18 maps_3.3.0 pkgbuild_1.2.0
[173] utf8_1.2.1 bslib_0.2.5.1 lattice_0.20-44 spatstat.sparse_2.0-0
[177] sqldf_0.4-11 curl_4.3.2 ggbeeswarm_0.6.0 leiden_0.3.8
[181] zip_2.2.0 Rttf2pt1_1.3.8 survival_3.2-11 rmarkdown_2.9
[185] desc_1.3.0 munsell_0.5.0 e1071_1.7-7 GenomeInfoDbData_1.2.6
[189] reshape2_1.4.4 gtable_0.3.0 spatstat.core_2.2-0 extrafont_0.17 7 Saving environment
save.image(paste0(PROJECT_loc, "/",Today,".",PROJECTNAME,".scrnaseq_results.RData"))| © 1979-2021 Sander W. van der Laan | s.w.vanderlaan-2[at]umcutrecht.nl | swvanderlaan.github.io. |
---
title: "Mapping CAC susceptibility loci with single-cell resolution in carotid plaques."
author: '[Sander W. van der Laan, PhD](https://swvanderlaan.github.io) | @swvanderlaan'
date: '`r Sys.Date()`'
output:
  html_notebook: 
    cache: yes
    code_folding: hide
    collapse: yes
    df_print: paged
    fig.align: center
    fig_caption: yes
    fig_height: 10
    fig_retina: 2
    fig_width: 12
    number_sections: yes
    theme: paper
    toc: yes
    toc_float:
      collapsed: no
      smooth_scroll: yes
mainfont: Helvetica
subtitle: A 'druggable-MI-targets' project
editor_options:
  chunk_output_type: inline
---
```{r global_options, include=FALSE}
# further define some knitr-options.
knitr::opts_chunk$set(fig.width = 12, fig.height = 8, fig.path = 'Figures/',
                      eval = TRUE, warning = FALSE, message = FALSE)
```

_Clean the environment._
```{r ClearEnvironment, echo = FALSE}
rm(list = ls())
```

_Set locations, and the working directory ..._
```{r LocalSystem, echo = FALSE}
### Operating System Version
### Mac Pro
# ROOT_loc = "/Volumes/EliteProQx2Media"
# GENOMIC_loc = "/Users/svanderlaan/iCloud/Genomics"

### MacBook
ROOT_loc = "/Users/slaan3/OneDrive - UMC Utrecht"
GENOMIC_loc = paste0(ROOT_loc, "/Genomics")

### Generic Locations
AEDB_loc = paste0(GENOMIC_loc, "/Athero-Express/AE-AAA_GS_DBs")
LAB_loc = paste0(GENOMIC_loc, "/LabBusiness")

RAWDATA = paste0(ROOT_loc, "/PLINK/_AE_ORIGINALS/AESCRNA/prepped_data")

PROJECT_loc = paste0(ROOT_loc, "/PLINK/analyses/lookups/AE_20200512_COL_MKAVOUSI_MBOS_CHARGE_1000G_CAC")
RESULTS = paste0(ROOT_loc, "/PLINK/analyses/lookups/AE_20200512_COL_MKAVOUSI_MBOS_CHARGE_1000G_CAC/scRNAseq")

TARGET_loc = paste0(GENOMIC_loc, "/Athero-Express/Forms/2020/AE_20200512_COL_MKAVOUSI_MBOS_CHARGE_1000G_CAC")

### SOME VARIABLES WE NEED DOWN THE LINE
cat("\nDefining phenotypes and datasets.\n")
PROJECTNAME="AESCRNA"

cat("\nCreate a new analysis directory, including subdirectories.\n")
# Analysis
ifelse(!dir.exists(file.path(RESULTS, "/",PROJECTNAME)), 
       dir.create(file.path(RESULTS, "/",PROJECTNAME)), 
       FALSE)
ANALYSIS_loc = paste0(RESULTS,"/",PROJECTNAME)

# Plots
ifelse(!dir.exists(file.path(ANALYSIS_loc, "/PLOTS")), 
       dir.create(file.path(ANALYSIS_loc, "/PLOTS")), 
       FALSE)
PLOT_loc = paste0(ANALYSIS_loc,"/PLOTS")

# QC plots
ifelse(!dir.exists(file.path(PLOT_loc, "/QC")), 
       dir.create(file.path(PLOT_loc, "/QC")), 
       FALSE)
QC_loc = paste0(PLOT_loc,"/QC")

# Output files
ifelse(!dir.exists(file.path(ANALYSIS_loc, "/OUTPUT")), 
       dir.create(file.path(ANALYSIS_loc, "/OUTPUT")), 
       FALSE)
OUT_loc = paste0(ANALYSIS_loc, "/OUTPUT")

cat("\nSetting working directory and listing its contents.\n")
setwd(paste0(RESULTS))
getwd()
list.files()
```

_... a package-installation function ..._
```{r Function: installations, echo=FALSE}
install.packages.auto <- function(x) { 
  x <- as.character(substitute(x)) 
  if(isTRUE(x %in% .packages(all.available = TRUE))) { 
    eval(parse(text = sprintf("require(\"%s\")", x)))
  } else { 
    # Update installed packages - this may mean a full upgrade of R, which in turn
    # may not be warrented. 
    # update.install.packages.auto(ask = FALSE) 
    eval(parse(text = sprintf("install.packages(\"%s\", dependencies = TRUE, repos = \"https://cloud.r-project.org/\")", x)))
  }
  if(isTRUE(x %in% .packages(all.available = TRUE))) { 
    eval(parse(text = sprintf("require(\"%s\")", x)))
  } else {
    if (!requireNamespace("BiocManager"))
      install.packages("BiocManager")
    # BiocManager::install() # this would entail updating installed packages, which in turned may not be warrented
    eval(parse(text = sprintf("BiocManager::install(\"%s\")", x)))
    eval(parse(text = sprintf("require(\"%s\")", x)))
  }
}
```

_... and load those packages._
```{r Setting: loading_packages, echo=FALSE}
install.packages.auto("readr")
install.packages.auto("optparse")
install.packages.auto("tools")
install.packages.auto("dplyr")
install.packages.auto("tidyr")
install.packages.auto("tidylog")
library("tidylog", warn.conflicts = FALSE)
install.packages.auto("naniar")

# To get 'data.table' with 'fwrite' to be able to directly write gzipped-files
# Ref: https://stackoverflow.com/questions/42788401/is-possible-to-use-fwrite-from-data-table-with-gzfile
# install.packages("data.table", repos = "https://Rdatatable.gitlab.io/data.table")
library(data.table)

install.packages.auto("tidyverse")
install.packages.auto("knitr")
install.packages.auto("DT")

install.packages.auto("org.Hs.eg.db")
install.packages.auto("mygene")
install.packages.auto("EnhancedVolcano")

install.packages.auto("haven")
install.packages.auto("tableone")

# install.packages.auto("Seurat") # latest version

# Install the devtools package from Hadley Wickham
install.packages.auto('devtools')
# Replace '2.3.4' with your desired version
# devtools::install_version(package = 'Seurat', version = package_version('2.3.4'))
# install.packages("Seurat")
library("Seurat")


```

_We will create a datestamp and define the Utrecht Science Park Colour Scheme_.
```{r Setting: Colors, echo=FALSE}

Today = format(as.Date(as.POSIXlt(Sys.time())), "%Y%m%d")
Today.Report = format(as.Date(as.POSIXlt(Sys.time())), "%A, %B %d, %Y")

### UtrechtScienceParkColoursScheme
###
### WebsitetoconvertHEXtoRGB:http://hex.colorrrs.com.
### Forsomefunctionsyoushoulddividethesenumbersby255.
### 
###	No.	Color			      HEX	(RGB)						              CHR		  MAF/INFO
###---------------------------------------------------------------------------------------
###	1	  yellow			    #FBB820 (251,184,32)				      =>	1		or 1.0>INFO
###	2	  gold			      #F59D10 (245,157,16)				      =>	2		
###	3	  salmon			    #E55738 (229,87,56)				      =>	3		or 0.05<MAF<0.2 or 0.4<INFO<0.6
###	4	  darkpink		    #DB003F ((219,0,63)				      =>	4		
###	5	  lightpink		    #E35493 (227,84,147)				      =>	5		or 0.8<INFO<1.0
###	6	  pink			      #D5267B (213,38,123)				      =>	6		
###	7	  hardpink		    #CC0071 (204,0,113)				      =>	7		
###	8	  lightpurple	    #A8448A (168,68,138)				      =>	8		
###	9	  purple			    #9A3480 (154,52,128)				      =>	9		
###	10	lavendel		    #8D5B9A (141,91,154)				      =>	10		
###	11	bluepurple		  #705296 (112,82,150)				      =>	11		
###	12	purpleblue		  #686AA9 (104,106,169)			      =>	12		
###	13	lightpurpleblue	#6173AD (97,115,173/101,120,180)	=>	13		
###	14	seablue			    #4C81BF (76,129,191)				      =>	14		
###	15	skyblue			    #2F8BC9 (47,139,201)				      =>	15		
###	16	azurblue		    #1290D9 (18,144,217)				      =>	16		or 0.01<MAF<0.05 or 0.2<INFO<0.4
###	17	lightazurblue	  #1396D8 (19,150,216)				      =>	17		
###	18	greenblue		    #15A6C1 (21,166,193)				      =>	18		
###	19	seaweedgreen	  #5EB17F (94,177,127)				      =>	19		
###	20	yellowgreen		  #86B833 (134,184,51)				      =>	20		
###	21	lightmossgreen	#C5D220 (197,210,32)				      =>	21		
###	22	mossgreen		    #9FC228 (159,194,40)				      =>	22		or MAF>0.20 or 0.6<INFO<0.8
###	23	lightgreen	  	#78B113 (120,177,19)				      =>	23/X
###	24	green			      #49A01D (73,160,29)				      =>	24/Y
###	25	grey			      #595A5C (89,90,92)				        =>	25/XY	or MAF<0.01 or 0.0<INFO<0.2
###	26	lightgrey		    #A2A3A4	(162,163,164)			      =>	26/MT
###
###	ADDITIONAL COLORS
###	27	midgrey			#D7D8D7
###	28	verylightgrey	#ECECEC"
###	29	white			#FFFFFF
###	30	black			#000000
###----------------------------------------------------------------------------------------------

uithof_color = c("#FBB820","#F59D10","#E55738","#DB003F","#E35493","#D5267B",
                 "#CC0071","#A8448A","#9A3480","#8D5B9A","#705296","#686AA9",
                 "#6173AD","#4C81BF","#2F8BC9","#1290D9","#1396D8","#15A6C1",
                 "#5EB17F","#86B833","#C5D220","#9FC228","#78B113","#49A01D",
                 "#595A5C","#A2A3A4", "#D7D8D7", "#ECECEC", "#FFFFFF", "#000000")

uithof_color_legend = c("#FBB820", "#F59D10", "#E55738", "#DB003F", "#E35493",
                        "#D5267B", "#CC0071", "#A8448A", "#9A3480", "#8D5B9A",
                        "#705296", "#686AA9", "#6173AD", "#4C81BF", "#2F8BC9",
                        "#1290D9", "#1396D8", "#15A6C1", "#5EB17F", "#86B833",
                        "#C5D220", "#9FC228", "#78B113", "#49A01D", "#595A5C",
                        "#A2A3A4", "#D7D8D7", "#ECECEC", "#FFFFFF", "#000000")

#ggplot2 default color palette
gg_color_hue <- function(n) {
  hues = seq(15, 375, length = n + 1)
  hcl(h = hues, l = 65, c = 100)[1:n]
}

### ----------------------------------------------------------------------------
```

# ERA-CVD 'druggable-MI-targets'
<!-- ![ERA-CVD logo]("Users/swvanderlaan/iCloud/Genomics/Projects/#Druggable-MI-Genes/Administration/ERA-CVD\ Logo_CMYK.jpg") -->

For the ERA-CVD 'druggable-MI-targets' project (grantnumber: 01KL1802) we will perform two related RNA sequencing (RNAseq) experiments:

1) conventional ('bulk') RNAseq using RNA extracted from carotid plaque samples, n ± 700. As of `r Today.Report` all samples have been selected and RNA has been extracted; quality control (QC) was performed and we have a dataset of 635 samples.

2) single-cell RNAseq (scRNAseq) of at least n = 40 samples (20 females, 20 males). As of `r Today.Report` data is available of 40 samples (3 females, 15 males), we are extending sampling to get more female samples.

Plaque samples are derived from carotid endarterectomies as part of the [Athero-Express Biobank Study](http:www/atheroexpress.nl) which is an ongoing study in the UMC Utrecht.


# Background

Here we map the CHARGE Consortium 1000G GWAS on _coronary artery calcification (CAC)_ susceptibility loci to the single-cell carotid plaque data. These are given in:

- `IndSigSNPsforSander.xlsx`
- `GeneList_15042020.xlsx`

```{r CAC targets}
library(openxlsx)

CAC_gene_list <- read.xlsx(paste0(PROJECT_loc, "/SNP/Genes.xlsx"))

CAC_variants <- read.xlsx(paste0(PROJECT_loc, "/SNP/Variants.xlsx"))


DT::datatable(CAC_gene_list)

DT::datatable(CAC_variants)

```

We will construct a list of genes to map to our scRNAseq data. 

```{r CAC targets for mapping}

target_genes <- unlist(CAC_gene_list$Gene)
target_genes
```


# Load data
First we will load the data:

- scRNAseq experimental data and rename the cell types.
- Athero-Express clinical data.

## AESCRNA: single-cell RNAseq from carotid plaques

Here we load the latest dataset from our Athero-Express Single Cell RNA experiment.

```{r LoadData}

scRNAseqData <- readRDS(paste0(RAWDATA, "/Seuset_40_patients/20210217_PlaqView_38_pts.RDS"))
scRNAseqData

```

The naming/classification is based on a combination conventional markers. We do not claim to know the exact identity of each cell, rather we refer to cells as 'KIT+ Mast cells"-like cells. Likewise we refer to the cell clusters as 'communities' of cells that exihibit similar properties, _i.e._ similar defining markers (_e.g. KIT_). 

We will rename the cell types to human readable names. 
```{r Change cell cummunity names}
### change names for clarity
backup.scRNAseqData = scRNAseqData
# get the old names to change to new names
UMAPPlot(backup.scRNAseqData, label = FALSE, pt.size = 1.25, label.size = 4, group.by = "ident")

levels(unique(backup.scRNAseqData@active.ident))

# "CD3+CD8A+ T cells I"         "CD3+CD8A+ T cells III"       "CD3+CD4+ T Cells I"          "CD14+CD68+ Macrophages I"   
# "Mixed Cells I"               "CD3+CD8A+ T Cells II"        "CD14+CD68+ Macrophages II"   "CD3+CD4+ T Cells II"        
# "ACTA2+ Smooth Muscle Cells"  "CD34+ Endothelial Cells I"   "CD34+ Endothelial Cells II"  "NCAM1+ Natural Killer Cells"
# "Mixed Cells II"              "CD79A+ B Cells I"            "CD14+CD68+ Macrophages III"  "CD3+ Regulatory T Cells"    
# "KIT+ Mast Cells"             "CD79A+ B Cells II" 

celltypes <- c("CD14+CD68+ Macrophages I" = "CD14+CD68+ M I", 
               "CD14+CD68+ Macrophages II" = "CD14+CD68+ M II", 
               "CD14+CD68+ Macrophages III" = "CD14+CD68+ M III",
               "CD3+CD8A+ T cells I" = "CD3+CD8A+ T I",
               "CD3+CD8A+ T Cells II" = "CD3+CD8A+ T II ", 
               "CD3+CD8A+ T cells III" = "CD3+CD8A+ T III", 
               "CD3+CD4+ T Cells I" = "CD3+CD4+ T I", 
               "CD3+CD4+ T Cells II" = "CD3+CD4+ T II", 
               "CD3+ Regulatory T Cells" = "CD3+ Treg", 
               "CD34+ Endothelial Cells I" = "CD34+ EC I", 
               "CD34+ Endothelial Cells II" = "CD34+ EC II", 
               "Mixed Cells I" = "Mixed I", 
               "Mixed Cells II" = "Mixed II", 
               "ACTA2+ Smooth Muscle Cells" = "ACTA2+ SMC", 
               "NCAM1+ Natural Killer Cells" = "NCAM1+ NK", 
               "KIT+ Mast Cells" = "KIT+ MC",
               "CD79A+ B Cells I" = "CD79A+ B I", 
               "CD79A+ B Cells II" = "CD79A+ B II")

scRNAseqData <- Seurat::RenameIdents(object = backup.scRNAseqData, 
                                       celltypes)
UMAPPlot(scRNAseqData, label = FALSE, pt.size = 1.25, label.size = 4, group.by = "ident")
```

```{r Change cell cummunity names - new plot}
UMAPPlot(scRNAseqData, label = TRUE, pt.size = 1.25, label.size = 4, group.by = "ident",
         repel = TRUE)

```

## Athero-Express Biobank Study: clinical data

Loading Athero-Express clinical data.
```{r LoadAEDB}
require(haven)

# AEDB <- haven::read_sav(paste0(AEDB_loc, "/2019-3NEW_AtheroExpressDatabase_ScientificAE_02072019_IC_added.sav"))
AEDB <- haven::read_sav(paste0(AEDB_loc, "/2020_1_NEW_AtheroExpressDatabase_ScientificAE_16-03-2020.sav"))

```

### Fix clinical data

We need to be very strict in defining _symptoms._ Therefore we will fix a new variable that groups _symptoms_ at inclusion.

Coding of _symptoms_ is as follows:

- missing	-999	
- Asymptomatic	0	
- TIA	1	
- minor stroke	2	
- Major stroke	3	
- Amaurosis fugax	4	
- Four vessel disease	5	
- Vertebrobasilary TIA	7	
- Retinal infarction	8	
- Symptomatic, but aspecific symtoms	9
- Contralateral symptomatic occlusion	10	
- retinal infarction	11	
- armclaudication due to occlusion subclavian artery, CEA needed for bypass	12	
- retinal infarction + TIAs	13	
- Ocular ischemic syndrome	14	
- ischemisch glaucoom	15	
- subclavian steal syndrome	16	
- TGA	17

We will group as follows:

1. Asymptomatic > 0
2. TIA > 1, 7, 13
3. Stroke > 2, 3
4. Ocular > 4, 14, 15
5. Retinal infarction > 8, 11
6. Other > 5, 9, 10, 12, 16, 17


```{r FixSymptoms, message=FALSE, warning=FALSE}

# Fix symptoms

attach(AEDB)
AEDB[,"Symptoms.5G"] <- NA
AEDB$Symptoms.5G[sympt == 0] <- "Asymptomatic"
AEDB$Symptoms.5G[sympt == 1 | sympt == 7 | sympt == 13] <- "TIA"
AEDB$Symptoms.5G[sympt == 2 | sympt == 3] <- "Stroke"
AEDB$Symptoms.5G[sympt == 4 | sympt == 14 | sympt == 15 ] <- "Ocular"
AEDB$Symptoms.5G[sympt == 8 | sympt == 11] <- "Retinal infarction"
AEDB$Symptoms.5G[sympt == 5 | sympt == 9 | sympt == 10 | sympt == 12 | sympt == 16 | sympt == 17] <- "Other"


# AsymptSympt
AEDB[,"AsymptSympt"] <- NA
AEDB$AsymptSympt[sympt == -999] <- NA
AEDB$AsymptSympt[sympt == 0] <- "Asymptomatic"
AEDB$AsymptSympt[sympt == 1 | sympt == 7 | sympt == 13 | sympt == 2 | sympt == 3] <- "Symptomatic"
AEDB$AsymptSympt[sympt == 4 | sympt == 14 | sympt == 15 | sympt == 8 | sympt == 11 | sympt == 5 | sympt == 9 | sympt == 10 | sympt == 12 | sympt == 16 | sympt == 17] <- "Ocular and others"

# AsymptSympt
AEDB[,"AsymptSympt2G"] <- NA
AEDB$AsymptSympt2G[sympt == -999] <- NA
AEDB$AsymptSympt2G[sympt == 0] <- "Asymptomatic"
AEDB$AsymptSympt2G[sympt == 1 | sympt == 7 | sympt == 13 | sympt == 2 | sympt == 3 | sympt == 4 | sympt == 14 | sympt == 15 | sympt == 8 | sympt == 11 | sympt == 5 | sympt == 9 | sympt == 10 | sympt == 12 | sympt == 16 | sympt == 17] <- "Symptomatic"

detach(AEDB)

# table(AEDB$sympt, useNA = "ifany")
# table(AEDB$AsymptSympt2G, useNA = "ifany")
# table(AEDB$Symptoms.5G, useNA = "ifany")
# 
# table(AEDB$AsymptSympt2G, AEDB$sympt, useNA = "ifany")
# table(AEDB$Symptoms.5G, AEDB$sympt, useNA = "ifany")
table(AEDB$AsymptSympt2G, AEDB$Symptoms.5G, useNA = "ifany")

# AEDB.temp <- subset(AEDB,  select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "sympt", "Symptoms.5G", "AsymptSympt"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# 
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
# 
# table(AEDB.temp$Symptoms.5G, AEDB.temp$AsymptSympt)
# 
# rm(AEDB.temp)
```

We will also fix the _plaquephenotypes_ variable.  

Coding of symptoms is as follows:

- missing	-999	
- not relevant -888
- fibrous	1	
- fibroatheromatous	2	
- atheromatous	3	


```{r FixPlaquePhenotypes, message=FALSE, warning=FALSE}

# Fix plaquephenotypes
attach(AEDB)
AEDB[,"OverallPlaquePhenotype"] <- NA
AEDB$OverallPlaquePhenotype[plaquephenotype == -999] <- NA
AEDB$OverallPlaquePhenotype[plaquephenotype == -999] <- NA
AEDB$OverallPlaquePhenotype[plaquephenotype == 1] <- "fibrous"
AEDB$OverallPlaquePhenotype[plaquephenotype == 2] <- "fibroatheromatous"
AEDB$OverallPlaquePhenotype[plaquephenotype == 3] <- "atheromatous"
detach(AEDB)

# AEDB.temp <- subset(AEDB,  select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "plaquephenotype", "OverallPlaquePhenotype"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# 
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
# 
# rm(AEDB.temp)

```

We will also fix the _diabetes_ status variable.

```{r FixDiabetes, message=FALSE, warning=FALSE}

# Fix diabetes
attach(AEDB)
AEDB[,"DiabetesStatus"] <- NA
AEDB$DiabetesStatus[DM.composite == -999] <- NA
AEDB$DiabetesStatus[DM.composite == 0] <- "Control (no Diabetes Dx/Med)"
AEDB$DiabetesStatus[DM.composite == 1] <- "Diabetes"
detach(AEDB)

table(AEDB$DM.composite, AEDB$DiabetesStatus)
# AEDB.temp <- subset(AEDB,  select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "DM.composite", "DiabetesStatus"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# AEDB.temp$DiabetesStatus <- to_factor(AEDB.temp$DiabetesStatus)
# 
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
# 
# rm(AEDB.temp)

```


We will also fix the _smoking_ status variable. We are interested in whether someone never, ever or is currently (at the time of inclusion) smoking. This is based on the questionnaire. 

- `diet801`: are you a smoker?
- `diet802`: did you smoke in the past?

We already have some variables indicating smoking status:

- `SmokingReported`: patient has reported to smoke.
- `SmokingYearOR`: smoking in the year of surgery?
- `SmokerCurrent`: currently smoking?



```{r FixSmoking, message=FALSE, warning=FALSE}
require(labelled)
AEDB$diet801 <- to_factor(AEDB$diet801)
AEDB$diet802 <- to_factor(AEDB$diet802)
AEDB$diet805 <- to_factor(AEDB$diet805)
AEDB$SmokingReported <- to_factor(AEDB$SmokingReported)
AEDB$SmokerCurrent <- to_factor(AEDB$SmokerCurrent)
AEDB$SmokingYearOR <- to_factor(AEDB$SmokingYearOR)

# table(AEDB$diet801)
# table(AEDB$diet802)
# table(AEDB$SmokingReported)
# table(AEDB$SmokerCurrent)
# table(AEDB$SmokingYearOR)
# table(AEDB$SmokingReported, AEDB$SmokerCurrent, useNA = "ifany", dnn = c("Reported smoking", "Current smoker"))
# 
# table(AEDB$diet801, AEDB$diet802, useNA = "ifany", dnn = c("Smoker", "Past smoker"))

cat("\nFixing smoking status.\n")
attach(AEDB)
AEDB[,"SmokerStatus"] <- NA
AEDB$SmokerStatus[diet802 == "don't know"] <- "Never smoked"
AEDB$SmokerStatus[diet802 == "I still smoke"] <- "Current smoker"
AEDB$SmokerStatus[SmokerCurrent == "no" & diet802 == "no"] <- "Never smoked"
AEDB$SmokerStatus[SmokerCurrent == "no" & diet802 == "yes"] <- "Ex-smoker"
AEDB$SmokerStatus[SmokerCurrent == "yes"] <- "Current smoker"
AEDB$SmokerStatus[SmokerCurrent == "no data available/missing"] <- NA
# AEDB$SmokerStatus[is.na(SmokerCurrent)] <- "Never smoked"
detach(AEDB)

cat("\n* Current smoking status.\n")
table(AEDB$SmokerCurrent,
      useNA = "ifany", 
      dnn = c("Current smoker"))

cat("\n* Updated smoking status.\n")
table(AEDB$SmokerStatus,
      useNA = "ifany", 
      dnn = c("Updated smoking status"))

cat("\n* Comparing to 'SmokerCurrent'.\n")
table(AEDB$SmokerStatus, AEDB$SmokerCurrent, 
      useNA = "ifany", 
      dnn = c("Updated smoking status", "Current smoker"))

# AEDB.temp <- subset(AEDB,  select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "DM.composite", "DiabetesStatus"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# AEDB.temp$DiabetesStatus <- to_factor(AEDB.temp$DiabetesStatus)
# 
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
# 
# rm(AEDB.temp)


```

We will also fix the _alcohol_ status variable.


```{r FixAlcohol, message=FALSE, warning=FALSE}

# Fix diabetes
attach(AEDB)
AEDB[,"AlcoholUse"] <- NA
AEDB$AlcoholUse[diet810 == -999] <- NA
AEDB$AlcoholUse[diet810 == 0] <- "No"
AEDB$AlcoholUse[diet810 == 1] <- "Yes"
detach(AEDB)

# AEDB.temp <- subset(AEDB,  select = c("STUDY_NUMBER", "UPID", "Age", "Gender", "Hospital", "Artery_summary", "diet810", "AlcoholUse"))
# require(labelled)
# AEDB.temp$Gender <- to_factor(AEDB.temp$Gender)
# AEDB.temp$Hospital <- to_factor(AEDB.temp$Hospital)
# AEDB.temp$Artery_summary <- to_factor(AEDB.temp$Artery_summary)
# AEDB.temp$AlcoholUse <- to_factor(AEDB.temp$AlcoholUse)
# 
# DT::datatable(AEDB.temp[1:10,], caption = "Excerpt of the whole AEDB.", rownames = FALSE)
# 
# rm(AEDB.temp)


```


### Prepare baseline characteristics

We are interested in the following variables at baseline.

- Age (years)
- Female sex (N, %)
- Hypertension (N, %)
- SBP (mmHg)
- DBP (mmHg)
- Diabetes mellitus (N, %)
- Total cholesterol levels (mg/dL)
- LDL cholesterol levels (mg/dL)
- HDL cholesterol levels (mg/dL)
- Triglyceride levels (mg/dL)
- Use of statins (N, %)
- Use of antiplatelet drugs (N, %)
- BMI (kg/m²)
- Smoking status (N, %)
  - Never smokers
  - Ex-smokers
  - Current smokers
- History of CAD (N, %)
- History of PAD (N, %)
- Clinical manifestations
  - Asymptomatic
  - Amaurosis fugax
  - TIA
  - Stroke
- eGFR (mL/min/1.73 m²)
- Testosterone (nmol/L)

```{r Baseline AEDB: preparation}
cat("====================================================================================================\n")
cat("SELECTION THE SHIZZLE\n")

### Artery levels
# AEdata$Artery_summary: 
#           value                                                                                   label
# NOT USE - 0 No artery known (yet), no surgery (patient ill, died, exited study), re-numbered to AAA
# USE - 1                                                                  carotid (left & right)
# USE - 2                                               femoral/iliac (left, right or both sides)
# NOT USE - 3                                               other carotid arteries (common, external)
# NOT USE - 4                                   carotid bypass and injury (left, right or both sides)
# NOT USE - 5                                                         aneurysmata (carotid & femoral)
# NOT USE - 6                                                                                   aorta
# NOT USE - 7                                            other arteries (renal, popliteal, vertebral)
# NOT USE - 8                        femoral bypass, angioseal and injury (left, right or both sides)

### AEdata$informedconsent
#           value                                                                                           label
# NOT USE - -999                                                                                         missing
# NOT USE - 0                                                                                        no, died
# USE - 1                                                                                             yes
# USE - 2                                                             yes, health treatment when possible
# USE - 3                                                                        yes, no health treatment
# USE - 4                                                yes, no health treatment, no commercial business
# NOT USE - 5                                                          yes, no tissue, no commerical business
# NOT USE - 6                      yes, no tissue, no questionnaires, no medical info, no commercial business
# USE - 7                             yes, no questionnaires, no health treatment, no commercial business
# USE - 8                                          yes, no questionnaires, health treatment when possible
# NOT USE - 9                  yes, no tissue, no questionnaires, no health treatment, no commerical business
# USE - 10                               yes, no health treatment, no medical info, no commercial business
# NOT USE - 11 yes, no tissue, no questionnaires, no health treatment, no medical info, no commercial business
# USE - 12                                                     yes, no questionnaires, no health treatment
# NOT USE - 13                                                             yes, no tissue, no health treatment
# NOT USE - 14                                                               yes, no tissue, no questionnaires
# NOT USE - 15                                                  yes, no tissue, health treatment when possible
# NOT USE - 16                                                                                  yes, no tissue
# USE - 17                                                                     yes, no commerical business
# USE - 18                                     yes, health treatment when possible, no commercial business
# USE - 19                                                    yes, no medical info, no commercial business
# USE - 20                                                                          yes, no questionnaires
# NOT USE - 21                         yes, no tissue, no questionnaires, no health treatment, no medical info
# NOT USE - 22                  yes, no tissue, no questionnaires, no health treatment, no commercial business
# USE - 23                                                                            yes, no medical info
# USE - 24                                                  yes, no questionnaires, no commercial business
# USE - 25                                    yes, no questionnaires, no health treatment, no medical info
# USE - 26                  yes, no questionnaires, health treatment when possible, no commercial business
# USE - 27                                                      yes,  no health treatment, no medical info
# NOT USE - 28                                                                             no, doesn't want to
# NOT USE - 29                                                                              no, unable to sign
# NOT USE - 30                                                                                 no, no reaction
# NOT USE - 31                                                                                        no, lost
# NOT USE - 32                                                                                     no, too old
# NOT USE - 34                                            yes, no medical info, health treatment when possible
# NOT USE - 35                                             no (never asked for IC because there was no tissue)
# USE - 36                    yes, no medical info, no commercial business, health treatment when possible
# NOT USE - 37                                                                                    no, endpoint
# USE - 38                                                         wil niets invullen, wel alles gebruiken
# USE - 39                                           second informed concents: yes, no commercial business
# NOT USE - 40                                                                              nooit geincludeerd

cat("- sanity checking PRIOR to selection")
library(data.table)
require(labelled)
ae.gender <- to_factor(AEDB$Gender)
ae.hospital <- to_factor(AEDB$Hospital)
table(ae.gender, ae.hospital, dnn = c("Sex", "Hospital"))
ae.artery <- to_factor(AEDB$Artery_summary)
table(ae.artery, ae.gender, dnn = c("Sex", "Artery"))

rm(ae.gender, ae.hospital, ae.artery)

# I change numeric and factors manually because, well, I wouldn't know how to fix it otherwise
# to have this 'tibble' work with 'tableone'... :-)

AEDB$Age <- as.numeric(AEDB$Age)
AEDB$diastoli <- as.numeric(AEDB$diastoli)
AEDB$systolic <- as.numeric(AEDB$systolic)

AEDB$TC_finalCU <- as.numeric(AEDB$TC_finalCU)
AEDB$LDL_finalCU <- as.numeric(AEDB$LDL_finalCU)
AEDB$HDL_finalCU <- as.numeric(AEDB$HDL_finalCU)
AEDB$TG_finalCU <- as.numeric(AEDB$TG_finalCU)

AEDB$TC_final <- as.numeric(AEDB$TC_final)
AEDB$LDL_final <- as.numeric(AEDB$LDL_final)
AEDB$HDL_final <- as.numeric(AEDB$HDL_final)
AEDB$TG_final <- as.numeric(AEDB$TG_final)

AEDB$Age <- as.numeric(AEDB$Age)
AEDB$GFR_MDRD <- as.numeric(AEDB$GFR_MDRD)
AEDB$BMI <- as.numeric(AEDB$BMI)
AEDB$eCigarettes <- as.numeric(AEDB$eCigarettes)
AEDB$ePackYearsSmoking <- as.numeric(AEDB$ePackYearsSmoking)
AEDB$EP_composite_time <- as.numeric(AEDB$EP_composite_time)

AEDB$macmean0 <- as.numeric(AEDB$macmean0)
AEDB$smcmean0 <- as.numeric(AEDB$smcmean0)
AEDB$neutrophils <- as.numeric(AEDB$neutrophils)
AEDB$Mast_cells_plaque <- as.numeric(AEDB$Mast_cells_plaque)
AEDB$vessel_density_averaged <- as.numeric(AEDB$vessel_density_averaged)

require(labelled)
AEDB$ORyear <- to_factor(AEDB$ORyear)
AEDB$Gender <- to_factor(AEDB$Gender)
AEDB$Hospital <- to_factor(AEDB$Hospital)
AEDB$KDOQI <- to_factor(AEDB$KDOQI)
AEDB$BMI_WHO <- to_factor(AEDB$BMI_WHO)
AEDB$DiabetesStatus <- to_factor(AEDB$DiabetesStatus)
AEDB$SmokerStatus <- to_factor(AEDB$SmokerStatus)
AEDB$AlcoholUse <- to_factor(AEDB$AlcoholUse)

AEDB$Hypertension.selfreport <- to_factor(AEDB$Hypertension1)
AEDB$Hypertension.selfreportdrug <- to_factor(AEDB$Hypertension2)
AEDB$Hypertension.composite <- to_factor(AEDB$Hypertension.composite)
AEDB$Hypertension.drugs <- to_factor(AEDB$Hypertension.drugs)

AEDB$Med.anticoagulants <- to_factor(AEDB$Med.anticoagulants)
AEDB$Med.all.antiplatelet <- to_factor(AEDB$Med.all.antiplatelet)
AEDB$Med.Statin.LLD <- to_factor(AEDB$Med.Statin.LLD)

AEDB$Stroke_Dx <- to_factor(AEDB$Stroke_Dx)
AEDB$CAD_history <- to_factor(AEDB$CAD_history)
AEDB$PAOD <- to_factor(AEDB$PAOD)
AEDB$Peripheral.interv <- to_factor(AEDB$Peripheral.interv)

AEDB$sympt <- to_factor(AEDB$sympt)
AEDB$Symptoms.3g <- to_factor(AEDB$Symptoms.3g)
AEDB$Symptoms.4g <- to_factor(AEDB$Symptoms.4g)
AEDB$Symptoms.5G <- to_factor(AEDB$Symptoms.5G)
AEDB$AsymptSympt <- to_factor(AEDB$AsymptSympt)
AEDB$AsymptSympt2G <- to_factor(AEDB$AsymptSympt2G)

AEDB$restenos <- to_factor(AEDB$restenos)
AEDB$stenose <- to_factor(AEDB$stenose)
AEDB$EP_composite <- to_factor(AEDB$EP_composite)
AEDB$Macrophages.bin <- to_factor(AEDB$Macrophages.bin)
AEDB$SMC.bin <- to_factor(AEDB$SMC.bin)
AEDB$IPH.bin <- to_factor(AEDB$IPH.bin)
AEDB$Calc.bin <- to_factor(AEDB$Calc.bin)
AEDB$Collagen.bin <- to_factor(AEDB$Collagen.bin)
AEDB$Fat.bin_10 <- to_factor(AEDB$Fat.bin_10)
AEDB$Fat.bin_40 <- to_factor(AEDB$Fat.bin_40)
AEDB$OverallPlaquePhenotype <- to_factor(AEDB$OverallPlaquePhenotype)

AEDB$Artery_summary <- to_factor(AEDB$Artery_summary)

AEDB$informedconsent <- to_factor(AEDB$informedconsent)

AEDB.CEA <- subset(AEDB,
                    (Artery_summary == "carotid (left & right)" | Artery_summary == "other carotid arteries (common, external)") & # we only want carotids
                       informedconsent != "missing" & # we are really strict in selecting based on 'informed consent'!
                       informedconsent != "no, died" &
                       informedconsent != "yes, no tissue, no commerical business" &
                       informedconsent != "yes, no tissue, no questionnaires, no medical info, no commercial business" &
                       informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commerical business" &
                       informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info, no commercial business" &
                       informedconsent != "yes, no tissue, no health treatment" &
                       informedconsent != "yes, no tissue, no questionnaires" &
                       informedconsent != "yes, no tissue, health treatment when possible" &
                       informedconsent != "yes, no tissue" &
                       informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info" &
                       informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commercial business" &
                       informedconsent != "no, doesn't want to" &
                       informedconsent != "no, unable to sign" &
                       informedconsent != "no, no reaction" &
                       informedconsent != "no, lost" &
                       informedconsent != "no, too old" &
                       informedconsent != "yes, no medical info, health treatment when possible" &
                       informedconsent != "no (never asked for IC because there was no tissue)" &
                       informedconsent != "no, endpoint" &
                       informedconsent != "nooit geincludeerd" & 
                     !is.na(AsymptSympt2G))
# AEDB.CEA[1:10, 1:10]
dim(AEDB.CEA)
```


```{r Baseline AEDB: creation}
cat("===========================================================================================\n")
cat("CREATE BASELINE TABLE\n")

# Baseline table variables
basetable_vars = c("Hospital", "ORyear",
                   "Age", "Gender", 
                   "TC_finalCU", "LDL_finalCU", "HDL_finalCU", "TG_finalCU", 
                   "TC_final", "LDL_final", "HDL_final", "TG_final", 
                   "systolic", "diastoli", "GFR_MDRD", "BMI", 
                   "KDOQI", "BMI_WHO", 
                   "SmokerStatus", "AlcoholUse",
                   "DiabetesStatus", 
                   "Hypertension.selfreport", "Hypertension.selfreportdrug", "Hypertension.composite", "Hypertension.drugs", 
                   "Med.anticoagulants", "Med.all.antiplatelet", "Med.Statin.LLD", 
                   "Stroke_Dx", "sympt", "Symptoms.5G", "AsymptSympt", "AsymptSympt2G",
                   "restenos", "stenose",
                   "CAD_history", "PAOD", "Peripheral.interv", 
                   "EP_composite", "EP_composite_time",
                   "macmean0", "smcmean0", "Macrophages.bin", "SMC.bin",
                   "neutrophils", "Mast_cells_plaque",
                   "IPH.bin", "vessel_density_averaged",
                   "Calc.bin", "Collagen.bin", 
                   "Fat.bin_10", "Fat.bin_40", "OverallPlaquePhenotype")

basetable_bin = c("Gender", 
                  "KDOQI", "BMI_WHO", 
                  "SmokerStatus", "AlcoholUse",
                  "DiabetesStatus", 
                  "Hypertension.selfreport", "Hypertension.selfreportdrug", "Hypertension.composite", "Hypertension.drugs", 
                  "Med.anticoagulants", "Med.all.antiplatelet", "Med.Statin.LLD", 
                  "Stroke_Dx", "sympt", "Symptoms.5G", "AsymptSympt", "AsymptSympt2G",
                  "restenos", "stenose",
                  "CAD_history", "PAOD", "Peripheral.interv", 
                  "EP_composite", "Macrophages.bin", "SMC.bin",
                  "IPH.bin", 
                  "Calc.bin", "Collagen.bin", 
                  "Fat.bin_10", "Fat.bin_40", "OverallPlaquePhenotype")
# basetable_bin

basetable_con = basetable_vars[!basetable_vars %in% basetable_bin]
# basetable_con
```

### Athero-Express Biobank Study: baseline characteristics
Showing the baseline table of the whole Athero-Express Biobank.
```{r Baseline AEDB: Visualize}
# Create baseline tables
# http://rstudio-pubs-static.s3.amazonaws.com/13321_da314633db924dc78986a850813a50d5.html
AEDB.CEA.tableOne = print(CreateTableOne(vars = basetable_vars, 
                                         # factorVars = basetable_bin,
                                         # strata = "Gender",
                                         data = AEDB.CEA, includeNA = TRUE), 
                          nonnormal = c(), missing = TRUE,
                          quote = FALSE, noSpaces = FALSE, showAllLevels = TRUE, explain = TRUE, 
                          format = "pf", 
                          contDigits = 3)[,1:3]

```


## AESCRNA: baseline characteristics

```{r Baseline: creation}
metadata <- scRNAseqData@meta.data %>% as_tibble() %>% separate(orig.ident, c("Patient", NA))
scRNAseqDataMeta <- metadata %>% distinct(Patient, .keep_all = TRUE)

scRNAseqDataMetaAE <- merge(scRNAseqDataMeta, AEDB, by.x = "Patient", by.y = "STUDY_NUMBER", sort = FALSE, all.x = TRUE)
dim(scRNAseqDataMetaAE)

# Replace missing data 
# Ref: https://cran.r-project.org/web/packages/naniar/vignettes/replace-with-na.html
require(naniar)

na_strings <- c("NA", "N A", "N / A", "N/A", "N/ A", 
                "Not Available", "Not available", 
                "missing", 
                "-999", "-99", 
                "No data available/missing", "No data available/Missing")
# Then you write ~.x %in% na_strings - which reads as “does this value occur in the list of NA strings”.

scRNAseqDataMetaAE %>%
  replace_with_na_all(condition = ~.x %in% na_strings)

cat("====================================================================================================")
cat("SELECTION THE SHIZZLE")

cat("- sanity checking PRIOR to selection")
library(data.table)
require(labelled)
ae.gender <- to_factor(scRNAseqDataMetaAE$Gender)
ae.hospital <- to_factor(scRNAseqDataMetaAE$Hospital)
table(ae.gender, ae.hospital, dnn = c("Sex", "Hospital"), useNA = "ifany")

ae.artery <- to_factor(scRNAseqDataMetaAE$Artery_summary)
table(ae.artery, ae.gender, dnn = c("Sex", "Artery"), useNA = "ifany")

ae.ic <- to_factor(scRNAseqDataMetaAE$informedconsent)
table(ae.ic, ae.gender, useNA = "ifany")

rm(ae.gender, ae.hospital, ae.artery, ae.ic)


scRNAseqDataMetaAE.all <- subset(scRNAseqDataMetaAE,
                            (Artery_summary == "carotid (left & right)" | Artery_summary == "other carotid arteries (common, external)" ) & # we only want carotids
                              informedconsent != "missing" & # we are really strict in selecting based on 'informed consent'!
                              informedconsent != "no, died" &
                              informedconsent != "yes, no tissue, no commerical business" &
                              informedconsent != "yes, no tissue, no questionnaires, no medical info, no commercial business" &
                              informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commerical business" &
                              informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info, no commercial business" &
                              informedconsent != "yes, no tissue, no health treatment" &
                              informedconsent != "yes, no tissue, no questionnaires" &
                              informedconsent != "yes, no tissue, health treatment when possible" &
                              informedconsent != "yes, no tissue" &
                              informedconsent != "yes, no tissue, no questionnaires, no health treatment, no medical info" &
                              informedconsent != "yes, no tissue, no questionnaires, no health treatment, no commercial business" &
                              informedconsent != "no, doesn't want to" &
                              informedconsent != "no, unable to sign" &
                              informedconsent != "no, no reaction" &
                              informedconsent != "no, lost" &
                              informedconsent != "no, too old" &
                              informedconsent != "yes, no medical info, health treatment when possible" & 
                              informedconsent != "no (never asked for IC because there was no tissue)" &
                              informedconsent != "no, endpoint" &
                              informedconsent != "nooit geincludeerd")
# scRNAseqDataMetaAE.all[1:10, 1:10]
dim(scRNAseqDataMetaAE.all)
# DT::datatable(scRNAseqDataMetaAE.all)

```

Showing the baseline table.
```{r Baseline: Visualize}
cat("===========================================================================================")
cat("CREATE BASELINE TABLE")

# Create baseline tables
# http://rstudio-pubs-static.s3.amazonaws.com/13321_da314633db924dc78986a850813a50d5.html
scRNAseqDataMetaAE.all.tableOne = print(CreateTableOne(vars = basetable_vars, 
                                                  # factorVars = basetable_bin,
                                                  # strata = "Gender",
                                                  data = scRNAseqDataMetaAE.all, includeNA = TRUE), 
                                   nonnormal = c(), 
                                   quote = FALSE, showAllLevels = TRUE,
                                   format = "p", 
                                   contDigits = 3)[,1:2]

```

Writing the baseline table to Excel format. 
```{r Baseline: write}
# Write basetable
require(openxlsx)
write.xlsx(file = paste0(OUT_loc, "/",Today,".",PROJECTNAME,".AE.BaselineTable.scRNAseq.xlsx"), 
           format(scRNAseqDataMetaAE.all.tableOne, digits = 5, scientific = FALSE) , rowNames = TRUE, colNames = TRUE)


```


# AESCRNA

## Quality control
Here review the number of cells per sample, plate, and patients. And plot the ratio's per sample and study number.
```{r QualityControl}
## check stuff
cat("\nHow many cells per type ...?")
sort(table(scRNAseqData@meta.data$SCT_snn_res.0.8))

# cat("\n\nHow many cells per plate ...?")
# sort(table(scRNAseqData@meta.data$ID))

# cat("\n\nHow many cells per type per plate ...?")
# table(scRNAseqData@meta.data$SCT_snn_res.0.8, scRNAseqData@meta.data$ID)

cat("\n\nHow many cells per patient ...?")
sort(table(scRNAseqData@meta.data$Patient))

cat("\n\nVisualizing these ratio's per study number and sample ...?")
UMAPPlot(scRNAseqData, label = TRUE, pt.size = 1.25, label.size = 4, group.by = "ident",
         repel = TRUE)
ggsave(paste0(PLOT_loc, "/", Today, ".UMAP.png"), plot = last_plot())
ggsave(paste0(PLOT_loc, "/", Today, ".UMAP.ps"), plot = last_plot())


# barplot(prop.table(x = table(scRNAseqData@active.ident, scRNAseqData@meta.data$Patient)), 
#         cex.axis = 1.0, cex.names = 0.5, las = 1,
#         col = uithof_color, xlab = "study number", legend.text = FALSE, args.legend = list(x = "bottom"))
# dev.copy(pdf, paste0(QC_loc, "/", Today, ".cell_ratios_per_sample.pdf"))
# dev.off()

# barplot(prop.table(x = table(scRNAseqData@active.ident, scRNAseqData@meta.data$ID)), 
#         cex.axis = 1.0, cex.names = 0.5, las = 2,
#         col = uithof_color, xlab = "sample ID", legend.text = FALSE, args.legend = list(x = "bottom"))
# dev.copy(pdf, paste0(QC_loc, "/", Today, ".cell_ratios_per_sample_per_plate.pdf"))
# dev.off()



```

## Visualisations

Let's project known cellular markers.

```{r Visualisation: tSNE Exploration}

UMAPPlot(scRNAseqData, label = FALSE, pt.size = 1.25, label.size = 4, group.by = "ident",
         repel = TRUE)

# endothelial cells
FeaturePlot(scRNAseqData, features = c("CD34"), cols =  c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("EDN1"), cols =  c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("EDNRA", "EDNRB"), cols =  c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("CDH5", "PECAM1"), cols =  c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("ACKR1"), cols =  c("#ECECEC", "#DB003F"))

# SMC
FeaturePlot(scRNAseqData, features = c("MYH11"), cols =  c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("LGALS3", "ACTA2"), cols =  c("#ECECEC", "#DB003F"))

# macrophages
FeaturePlot(scRNAseqData, features = c("CD14", "CD68"), cols =  c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("CD36"), cols =  c("#ECECEC", "#DB003F"))

# t-cells
FeaturePlot(scRNAseqData, features = c("CD3E"), cols =  c("#ECECEC", "#DB003F"))
FeaturePlot(scRNAseqData, features = c("CD4"), cols =  c("#ECECEC", "#DB003F"))
# FeaturePlot(scRNAseqData, features = c("CD8"), cols =  c("#ECECEC", "#DB003F"))

# b-cells
FeaturePlot(scRNAseqData, features = c("CD79A"), cols =  c("#ECECEC", "#DB003F"))

# mast cells
FeaturePlot(scRNAseqData, features = c("KIT"), cols =  c("#ECECEC", "#DB003F"))

# NK cells
FeaturePlot(scRNAseqData, features = c("NCAM1"), cols =  c("#ECECEC", "#DB003F"))

```


## Targets of interest: 

We check whether the targets genes, _`r target_genes`_, were sequenced using our method (STARseq). 

Several genes are not present or have different names, these are listed here, and were manually removed from/changed in the list.

- _AC011294.3_ ==> not found
- _C6orf195_ => _LINC01600_ replacement, not found
- _C9orf53_ => _CDKN2A-DT_ replacement, not found
- _AL137026.1_ ==> not found
- _DUPD1_ => _DUSP29_ replacement, not found
- _RP11-145E5.5_ ==> not found
- _PVRL2_ => _NECTIN2_ replacement
- _KIAA1462_ => _JCAD_ replacement
- _ZNF32_ ==> not found
- _BCAM_ ==> not found

```{r list target genes}
target_genes
```

### Expression in cell communities
```{r Visualisation: preparation}

target_genes_rm <- c("AC011294.3", "C6orf195", "C9orf53", "AL137026.1", "DUPD1", "RP11-145E5.5", "PVRL2",
                     "RP1-257A7.4", "RP1-257A7.5", "KIAA1462",
                     "ZNF32", "BCAM")

temp = target_genes[!target_genes %in% target_genes_rm]

target_genes_qc <- c(temp, "NECTIN2", "JCAD")

target_genes_qc

```

```{r Visualisation: Targets Feature and Dot Plots, message=FALSE, warning=FALSE}
library(RColorBrewer)

p1 <- DotPlot(scRNAseqData, features = target_genes_qc,
        cols = "RdBu")

p1 + theme(axis.text.x = element_text(angle = 45, hjust=1, size = 5))

ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.Targets.png"), plot = last_plot())
ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.Targets.ps"), plot = last_plot())

rm(p1)

# FeaturePlot(scRNAseqData, features = c(target_genes_qc),
#             cols =  c("#ECECEC", "#DB003F", "#9A3480","#1290D9"),
#             combine = TRUE)
# 
# ggsave(paste0(PLOT_loc, "/", Today, ".FeaturePlot.Targets.png"), plot = last_plot())
# ggsave(paste0(PLOT_loc, "/", Today, ".FeaturePlot.Targets.ps"), plot = last_plot())


```

```{r Visualisation: Targets}
# VlnPlot(scRNAseqData, features = "DUSP29")

for (GENE in target_genes_qc){
  print(paste0("Projecting the expression of ", GENE, "."))

  vp1 <-  VlnPlot(scRNAseqData, features = GENE) + 
    xlab("cell communities") + 
    ylab(bquote("normalized expression")) +
    theme(axis.title.x = element_text(color = "#000000", size = 14, face = "bold"), 
            axis.title.y = element_text(color = "#000000", size = 14, face = "bold"), 
            legend.position = "none")
    ggsave(paste0(PLOT_loc, "/", Today, ".VlnPlot.",GENE,".png"), plot = last_plot())
    ggsave(paste0(PLOT_loc, "/", Today, ".VlnPlot.",GENE,".ps"), plot = last_plot())
  
  # print(vp1)
  
}

```



### Differential expression between cell communities

Here we project genes to only the broad cell communities: 

- macrophages
- endothelial cells
- smooth muscle cells
- T-cells
- B-cells
- Mast cells
- NK-cells
- Mixed cells


#### Macrophages

Comparison between the macrophages cell communities (_CD14/CD68_<sup>+</sup>), and all other communities.
```{r Visualisation: Volcano MAC calculate}
N_GENES=20552
MAC.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III"), 
                          ident.2 = c(#"CD14+CD68+ M I", 
                                      #"CD14+CD68+ M II", 
                                      #"CD14+CD68+ M III",
                                      "CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg", 
                                      "CD34+ EC I", "CD34+ EC II",
                                      "Mixed I", 
                                      "Mixed II", 
                                      "ACTA2+ SMC", 
                                      "NCAM1+ NK", 
                                      "KIT+ MC",
                                      "CD79A+ B I", 
                                      "CD79A+ B II"))

DT::datatable(MAC.markers)
```

```{r Visualisation: Volcano MAC, message=FALSE, warning=FALSE}
MAC_Volcano_TargetsA = EnhancedVolcano(MAC.markers,
    lab = rownames(MAC.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "Macrophage markers\n(Macrophage communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
MAC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.MAC.DEG.Targets.pdf"), 
       plot = MAC_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results MAC}
library(tibble)
MAC.markers <- add_column(MAC.markers, Gene = row.names(MAC.markers), .before = 1)

temp <- MAC.markers[MAC.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results MAC: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".MAC.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```


#### Smooth muscle cells

Comparison between the smooth muscle cell communities (_ACTA2_<sup>+</sup>), and all other communities.
```{r Visualisation: Volcano SMC calculate}
N_GENES=20552
SMC.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("ACTA2+ SMC"), 
                          ident.2 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III",
                                      "CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg", 
                                      "CD34+ EC I", "CD34+ EC II",
                                      "Mixed I", 
                                      "Mixed II", 
                                      # "ACTA2+ SMC", 
                                      "NCAM1+ NK", 
                                      "KIT+ MC",
                                      "CD79A+ B I", 
                                      "CD79A+ B II"))

DT::datatable(SMC.markers)
```

```{r Visualisation: Volcano SMC, message=FALSE, warning=FALSE}
SMC_Volcano_TargetsA = EnhancedVolcano(SMC.markers,
    lab = rownames(SMC.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "SMC markers\n(SMC communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
SMC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.SMC.DEG.Targets.pdf"), 
       plot = SMC_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results SMC}
library(tibble)
SMC.markers <- add_column(SMC.markers, Gene = row.names(SMC.markers), .before = 1)

temp <- SMC.markers[SMC.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results SMC: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".SMC.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```


#### Endothelial cells

Comparison between the endothelial cell communities (_CD34_<sup>+</sup>), and all other communities.
```{r Visualisation: Volcano EC calculate}
N_GENES=20552
EC.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("CD34+ EC I", "CD34+ EC II"), 
                          ident.2 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III",
                                      "CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg", 
                                      # "CD34+ EC I", "CD34+ EC II",
                                      "Mixed I", 
                                      "Mixed II", 
                                      "ACTA2+ SMC",
                                      "NCAM1+ NK", 
                                      "KIT+ MC",
                                      "CD79A+ B I", 
                                      "CD79A+ B II"))

DT::datatable(EC.markers)
```

```{r Visualisation: Volcano EC, message=FALSE, warning=FALSE}
EC_Volcano_TargetsA = EnhancedVolcano(EC.markers,
    lab = rownames(EC.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "Endothelial cell markers\n(EC communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
EC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.EC.DEG.Targets.pdf"), 
       plot = EC_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results EC}
library(tibble)
EC.markers <- add_column(EC.markers, Gene = row.names(EC.markers), .before = 1)

temp <- EC.markers[EC.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results EC: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".EC.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```

#### T-cells

Comparison between the T-cell communities (_CD3/CD4/CD8_<sup>+</sup>), and all other communities.
```{r Visualisation: Volcano Tcell calculate}
N_GENES=20552
TC.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg"), 
                          ident.2 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III",
                                      # "CD3+CD8+ T I",
                                      # "CD3+CD8A+ T II ", 
                                      # "CD3+CD8 T III", 
                                      # "CD3+CD4+ T I", 
                                      # "CD3+CD4+ T II", 
                                      # "CD3+CD4+ T III", 
                                      "CD34+ EC I", "CD34+ EC II",
                                      "Mixed I", 
                                      "Mixed II", 
                                      "ACTA2+ SMC",
                                      "NCAM1+ NK", 
                                      "KIT+ MC",
                                      "CD79A+ B I", 
                                      "CD79A+ B II"))

DT::datatable(TC.markers)
```

```{r Visualisation: Volcano Tcell, message=FALSE, warning=FALSE}
TC_Volcano_TargetsA = EnhancedVolcano(TC.markers,
    lab = rownames(TC.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "T-cell markers\n(T-cell communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
TC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.TC.DEG.Targets.pdf"), 
       plot = TC_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results TC}
library(tibble)
TC.markers <- add_column(TC.markers, Gene = row.names(TC.markers), .before = 1)

temp <- TC.markers[TC.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results TC: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".TC.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```


#### B-cells

Comparison between the B-cell communities (_CD79A_<sup>+</sup>), and all other communities.
```{r Visualisation: Volcano Bcell calculate}
N_GENES=20552
BC.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("CD79A+ B I", 
                                      "CD79A+ B II"), 
                          ident.2 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III",
                                      "CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg", 
                                      "CD34+ EC I", "CD34+ EC II",
                                      "Mixed I", 
                                      "Mixed II", 
                                      "ACTA2+ SMC",
                                      "NCAM1+ NK", 
                                      "KIT+ MC"))

DT::datatable(BC.markers)
```

```{r Visualisation: Volcano Bcell, message=FALSE, warning=FALSE}
BC_Volcano_TargetsA = EnhancedVolcano(BC.markers,
    lab = rownames(BC.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "B-cell markers\n(B-cell communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
BC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.BC.DEG.Targets.pdf"), 
       plot = BC_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results BC}
library(tibble)
BC.markers <- add_column(BC.markers, Gene = row.names(BC.markers), .before = 1)

temp <- BC.markers[BC.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results BC: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".BC.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```


#### Mast cells

Comparison between the mast cell communities (_KIT_<sup>+</sup>), and all other communities.
```{r Visualisation: Volcano Mast calculate}
N_GENES=20552
MC.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("KIT+ MC"), 
                          ident.2 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III",
                                      "CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg", 
                                      "CD34+ EC I", "CD34+ EC II",
                                      "Mixed I", 
                                      "Mixed II", 
                                      "ACTA2+ SMC",
                                      "NCAM1+ NK", 
                                      # "KIT+ MC",
                                      "CD79A+ B I", 
                                      "CD79A+ B II"))

DT::datatable(MC.markers)
```

```{r Visualisation: Volcano Mast, message=FALSE, warning=FALSE}
MC_Volcano_TargetsA = EnhancedVolcano(MC.markers,
    lab = rownames(MC.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "Mast cell markers\n(Mast cell communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
MC_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.MC.DEG.Targets.pdf"), 
       plot = MC_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results MC}
library(tibble)
MC.markers <- add_column(MC.markers, Gene = row.names(MC.markers), .before = 1)

temp <- MC.markers[MC.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results MC: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".MC.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```


#### NK-cells

Comparison between the natural killer cell communities (_NCAM1_<sup>+</sup>), and all other communities.
```{r Visualisation: Volcano NK calculate}
N_GENES=20552
NK.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("NCAM1+ NK"), 
                          ident.2 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III",
                                      "CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg", 
                                      "CD34+ EC I", "CD34+ EC II",
                                      "Mixed I",
                                      "Mixed II",
                                      #"NCAM1+ NK",
                                      "ACTA2+ SMC", 
                                      "KIT+ MC",
                                      "CD79A+ B I", 
                                      "CD79A+ B II"))

DT::datatable(NK.markers)
```

```{r Visualisation: Volcano NK, message=FALSE, warning=FALSE}
NK_Volcano_TargetsA = EnhancedVolcano(NK.markers,
    lab = rownames(NK.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "NK markers\n(NK-cell communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
NK_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.NK.DEG.Targets.pdf"), 
       plot = NK_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results NK}
library(tibble)
NK.markers <- add_column(NK.markers, Gene = row.names(NK.markers), .before = 1)

temp <- NK.markers[NK.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results NK: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".NK.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```

#### Mixed cells

Comparison between the mixed cell communities, and all other communities.
```{r Visualisation: Volcano MIXED calculate}
N_GENES=20552
MIXED.markers <- FindMarkers(object = scRNAseqData, 
                          ident.1 = c("Mixed I", 
                                      "Mixed II"), 
                          ident.2 = c("CD14+CD68+ M I", 
                                      "CD14+CD68+ M II", 
                                      "CD14+CD68+ M III",
                                      "CD3+CD8A+ T I",
                                      "CD3+CD8A+ T II ", 
                                      "CD3+CD8A+ T III", 
                                      "CD3+CD4+ T I", 
                                      "CD3+CD4+ T II", 
                                      "CD3+ Treg", 
                                      "CD34+ EC I", "CD34+ EC II",
                                      # "Mixed I", 
                                      # "Mixed II", 
                                      "ACTA2+ SMC", 
                                      "NCAM1+ NK", 
                                      "KIT+ MC",
                                      "CD79A+ B I", 
                                      "CD79A+ B II"))

DT::datatable(MIXED.markers)
```

```{r Visualisation: Volcano MIXED, message=FALSE, warning=FALSE}
MIXED_Volcano_TargetsA = EnhancedVolcano(MIXED.markers,
    lab = rownames(MIXED.markers),
    x = "avg_log2FC",
    y = "p_val_adj",
    selectLab = target_genes_qc,
    axisLabSize = 12,
    xlab = "average fold-change",
    title = "Mixed markers\n(Mixed cell communities vs the rest)",
    titleLabSize = 14,
    pCutoff = 0.05/N_GENES, # 20552 genes
    FCcutoff = 1.25,
    pointSize = 1.5,
    labSize = 3.0,
    legendLabels =c('NS','avg. fold-change','P',
      'P & avg. fold-change'),
    legendPosition = "right",
    legendLabSize = 10,
    legendIconSize = 3.0,
    drawConnectors = TRUE,
    widthConnectors = 0.2,
    colConnectors = "#595A5C",
    gridlines.major = FALSE,
    gridlines.minor = FALSE)
MIXED_Volcano_TargetsA
ggsave(paste0(PLOT_loc, "/", Today, ".Volcano.MIXED.DEG.Targets.pdf"), 
       plot = MIXED_Volcano_TargetsA)
```

The target results are given below and written to a file.
```{r Results MIXED}
library(tibble)
MIXED.markers <- add_column(MIXED.markers, Gene = row.names(MIXED.markers), .before = 1)

temp <- MIXED.markers[MIXED.markers$Gene %in% target_genes_qc,]

DT::datatable(temp)
```

```{r Results MIXED: writing}
fwrite(temp, file = paste0(OUT_loc, "/", Today, ".MIXED.DEG.Targets.txt"),
       quote = FALSE,
       sep = "\t", 
       showProgress = FALSE, verbose = FALSE)
```


# Top hits

Dotplots of known and novel genes.

Some genes were not found in our data.

- DMRTA1 (known)
- LINC00841 (novel)
- LOC100130539 (novel)

```{r}
library(RColorBrewer)
# "C6orf195"     "EDN1"         "PHACTR1"      "TBC1D7"       "GFOD1"        "ENPP1"        "ENPP3"        "IGFBP3"      
# "AC011294.3"   "MTAP"         "RP11-145E5.5" "C9orf53"      "CDKN2A"       "CDKN2B"       "ZNF485"       "ZNF32"       
# "AL137026.1"   "ARID5B"       "RTKN2"        "CAMK2G"       "VCL"          "AP3M1"        "ADK"          "KAT6B"       
# "DUPD1"        "DUSP13"       "SAMD8"        "VDAC2"        "COMTD1"       "FGF23"        "COL4A1"       "COL4A2"      
# "CHRNA5"       "CHRNB4"       "ADAMTS7"      "MORF4L1"      "CTSH"         "BCAM"         "PVRL2"        "TOMM40"      
# "APOE"         "APOC1"       

tophits_known <- c("PHACTR1", "CDKN2B-AS1","APOE") # DMRTA1 not found in the data
tophits_novel <- c("ENPP3", "ENPP1", "IGFBP3","ARID5B","ADK", "FGF23", "COL4A2", "ADAMTS7", "MORF4L1") # "LINC00841", "LOC100130539" not found in the data


p1 <- DotPlot(scRNAseqData, features = tophits_known,
        cols = "RdBu")

p1 + theme(axis.text.x = element_text(angle = 45, hjust=1, size = 5))

ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.known.png"), plot = last_plot())
ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.known.ps"), plot = last_plot())

rm(p1)

p1 <- DotPlot(scRNAseqData, features = tophits_novel,
        cols = "RdBu")

p1 + theme(axis.text.x = element_text(angle = 45, hjust=1, size = 5))

ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.novel.png"), plot = last_plot())
ggsave(paste0(PLOT_loc, "/", Today, ".DotPlot.TopHits.novel.ps"), plot = last_plot())

rm(p1)


```


# Session information

------

    Version:      v1.0.2
    Last update:  2021-07-15
    Written by:   Sander W. van der Laan (s.w.vanderlaan-2[at]umcutrecht.nl).
    Description:  Script to load single-cell RNA sequencing (scRNAseq) data, and perform quality control (QC), and initial mapping to cells.
    Minimum requirements: R version 3.5.2 (2018-12-20) -- 'Eggshell Igloo', macOS Mojave (10.14.2).
    
    Change log
    * v1.0.2 Update to the gene list, workflow, and dataset.
    * v1.0.1 Update to the gene list.
    * v1.0.0 Initial version

------

```{r eval = TRUE}
sessionInfo()
```

# Saving environment
```{r Saving}
save.image(paste0(PROJECT_loc, "/",Today,".",PROJECTNAME,".scrnaseq_results.RData"))
```

------
<sup>&copy; 1979-2021 Sander W. van der Laan | s.w.vanderlaan-2[at]umcutrecht.nl | [swvanderlaan.github.io](https://swvanderlaan.github.io).</sup>
------

